Ross M B, Buzdar A U, Smith T L, Eckles N, Hortobagyi G N, Blumenschein G R, Freireich E J, Gehan E A
Cancer. 1985 Jan 15;55(2):341-6. doi: 10.1002/1097-0142(19850115)55:2<341::aid-cncr2820550206>3.0.co;2-7.
Groups of patients with newly diagnosed metastatic breast cancer who were consecutively registered into a breast cancer clinic beginning January 1956 (210 patients), January 1966 (210 patients), and January 1975 (251 patients), were analyzed to determine the impact on survival of the various treatment modalities utilized in each decade. Comparisons of survival were made among subgroups of patients with similar prognostic features. Except for patients with very poor performance status, all subgroups showed a significantly improved survival in the 1970s compared with the earlier decades. Combination chemotherapy was considered to be the major factor in the survival improvement.
对1956年1月（210例患者）、1966年1月（210例患者）和1975年1月（251例患者）开始连续登记入一家乳腺癌诊所的新诊断转移性乳腺癌患者组进行分析，以确定每个十年中使用的各种治疗方式对生存的影响。对具有相似预后特征的患者亚组进行了生存比较。除了身体状况非常差的患者外，所有亚组在20世纪70年代的生存率与早期几十年相比都有显著提高。联合化疗被认为是生存率提高的主要因素。
