Popa Liliana G, Gradinaru Teodora Cristiana, Giurcaneanu Calin, Tudose Irina, Vivisenco Cristina Iolanda, Beiu Cristina
Dermatology, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
Dermatology, Elias Emergency University Hospital, Bucharest, ROU.
Cureus. 2024 Nov 7;16(11):e73218. doi: 10.7759/cureus.73218. eCollection 2024 Nov.
Disseminated superficial porokeratosis (DSP) is a very uncommon dermatologic condition of unknown etiology, characterized by the clonal proliferation of atypical keratinocytes associated with aberrant keratinocyte differentiation. These lead to the development of the specific cornoid lamella that separates atypical from normal keratinocytes. DSP is most frequently encountered in immunosuppressed patients. It has been described in patients receiving immunosuppressive treatments, organ transplantation and in patients diagnosed with human immunodeficiency virus, hepatitis B and hepatitis C virus infection. We present the case of a 78-year-old patient who developed disseminated non-actinic after multiple trauma and major orthopedic surgery. To our knowledge, this is the first case of DSP occurring as a consequence of post-traumatic immunosuppression reported in the medical literature. We discuss the pathogenic mechanisms, as well as the optimal diagnostic and therapeutic approach in such cases.
播散性浅表性光化性角化病（DSP）是一种病因不明的非常罕见的皮肤病，其特征是与异常角质形成细胞分化相关的非典型角质形成细胞的克隆性增殖。这些导致了将非典型角质形成细胞与正常角质形成细胞分开的特定鸡眼样板的形成。DSP最常见于免疫抑制患者。在接受免疫抑制治疗、器官移植的患者以及被诊断患有人类免疫缺陷病毒、乙型肝炎和丙型肝炎病毒感染的患者中均有描述。我们报告了一例78岁患者，在多次创伤和大型骨科手术后发生播散性非光化性DSP。据我们所知，这是医学文献中报道的首例因创伤后免疫抑制而发生的DSP病例。我们讨论了其发病机制以及此类病例的最佳诊断和治疗方法。
