异色变体及其与肿瘤的关联。II. 白血病前期状态。

Heterochromatic variants and their association with neoplasias. II. Preleukemic states.

作者信息

Labal de Vinuesa M, Larripa I, Mudry de Pargament M, Brieux de Salum S

出版信息

Cancer Genet Cytogenet. 1985 Jan 1;14(1-2):31-5. doi: 10.1016/0165-4608(85)90212-2.

Abstract

A study of the heteromorphism of chromosomes #1, #9, and #16 was performed in the cells of 55 normal subjects and in those of 40 preleukemic patients including those with refractory anemia (RA) and sideroblastic anemia (SA), classified on the basis of the FAB nomenclature. Heteromorphism was present in 85% of the preleukemic patients, compared with 44% in normal controls (p less than 0.01). The patient population presented an increased incidence of C-band size variants in chromosome #1 (1qh+ and 1qh-), while chromosomes #9 and #16 showed no difference, compared with the findings in the control group.

摘要

对55名正常受试者以及40名根据FAB命名法分类的白血病前期患者（包括难治性贫血（RA）和铁粒幼细胞贫血（SA）患者）的细胞进行了1号、9号和16号染色体异态性研究。白血病前期患者中85%存在异态性，而正常对照组为44%（p<0.01）。与对照组结果相比，患者群体中1号染色体C带大小变异（1qh+和1qh-）的发生率增加，而9号和16号染色体无差异。