Wijns W, Serruys P W, Reiber J H, van den Brand M, Simoons M L, Kooijman C J, Balakumaran K, Hugenholtz P G
Circulation. 1985 Feb;71(2):273-9. doi: 10.1161/01.cir.71.2.273.
To evaluate, during cardiac catheterization, what constitutes a physiologically significant obstruction to blood flow in the human coronary system, computer-based quantitative analysis of coronary angiograms was performed on the angiograms of 31 patients with isolated disease of the proximal left anterior descending coronary artery. The angiographic severity of stenosis was compared with the transstenotic pressure gradient measured with the dilation catheter during angioplasty and with the results of exercise thallium scintigraphy. A curvilinear relationship was found between the pressure gradient across the stenosis (normalized for the mean aortic pressure) and the residual minimal area of obstruction (after subtracting the area of the angioplasty catheter). This relationship was best fitted by the equation: normalized mean pressure gradient = a + b . log [obstruction area], r = .74. The measurements of the percent area of stenosis (cutoff 80%) and of the transstenotic pressure gradient (cutoff 0.30) obtained at rest correctly predicted the occurrence of thallium perfusion defects induced by exercise in 83% of the patients.
为了在心脏导管插入术期间评估在人类冠状动脉系统中对血流构成生理上显著阻碍的因素，对31例孤立性左前降支近端冠状动脉疾病患者的血管造影进行了基于计算机的冠状动脉造影定量分析。将狭窄的血管造影严重程度与血管成形术期间用扩张导管测量的跨狭窄压力梯度以及运动铊闪烁显像结果进行比较。发现跨狭窄压力梯度（相对于平均主动脉压进行归一化）与残余最小阻塞面积（减去血管成形术导管面积后）之间存在曲线关系。这种关系最适合用以下方程表示：归一化平均压力梯度=a + b.log[阻塞面积]，r = 0.74。静息时获得的狭窄面积百分比测量值（截断值80%）和跨狭窄压力梯度测量值（截断值0.30）正确预测了83%的患者运动诱发的铊灌注缺损的发生情况。
