Behera Maheswari, Singh Lakshmi, Pradhan Biswajita, Behera Kanhu Charan
Department of Botany, College of Basic Science and Humanities, Odisha University of Agriculture and Technology, Bhubaneswar, Odisha, India.
Department of Botany, Model Degree College, Rayagada, Odisha, India.
Chem Biodivers. 2025 May;22(5):e202401613. doi: 10.1002/cbdv.202401613. Epub 2024 Dec 17.
Cancer remains a major global health concern, with breast cancer being particularly challenging. To address this, new therapeutic strategies are being explored, including natural alternatives. Seaweeds, rich in bioactive compounds, have gained attention for their therapeutic potential. Traditionally valued for their nutritional content, seaweed-derived compounds such as polysaccharides, polyphenols, sterols, vitamins, minerals, and carotenoids have shown anticancer properties. These compounds can modulate key cellular processes like apoptosis, angiogenesis, and inflammation-crucial in cancer progression. Their antioxidant, anti-inflammatory, and immunomodulatory effects make them promising candidates for complementary cancer therapies. Key bioactive components like fucoidans, laminarins, phlorotannins, and carotenoids exhibit antiproliferative, proapoptotic, antiangiogenic, and antimetastatic properties. Recent studies focus on the ability of these compounds to induce apoptosis in cancer cells. This review highlights the chemical constituents of various seaweed species with antitumor activity, their mechanisms of action, and the potential for integration into cancer treatments. It also addresses challenges in clinical applications and outlines future research directions for leveraging these marine resources in breast cancer therapy.
癌症仍然是全球主要的健康问题，其中乳腺癌尤其具有挑战性。为了解决这一问题，人们正在探索新的治疗策略，包括天然替代品。富含生物活性化合物的海藻因其治疗潜力而受到关注。海藻传统上因其营养成分而受到重视，海藻衍生的化合物，如多糖、多酚、甾醇、维生素、矿物质和类胡萝卜素，已显示出抗癌特性。这些化合物可以调节关键的细胞过程，如细胞凋亡、血管生成和炎症，这些过程在癌症进展中至关重要。它们的抗氧化、抗炎和免疫调节作用使它们成为辅助癌症治疗的有希望的候选者。岩藻聚糖、海带多糖、褐藻多酚和类胡萝卜素等关键生物活性成分具有抗增殖、促凋亡、抗血管生成和抗转移特性。最近的研究集中在这些化合物诱导癌细胞凋亡的能力上。本综述重点介绍了具有抗肿瘤活性的各种海藻物种的化学成分、它们的作用机制以及整合到癌症治疗中的潜力。它还讨论了临床应用中的挑战，并概述了在乳腺癌治疗中利用这些海洋资源的未来研究方向。
