Iyidal Ayşegül Yalçınkaya, Erduran Funda, Hayran Yıldız, Karadağ Yeşim Sücüllü
Department of Dermatology, Ankara Bilkent City Hospital, Çankaya/Ankara, Türkiye.
Department of Neurology, University of Health Sciences, Ankara Bilkent City Hospital, Çankaya/Ankara, Türkiye.
Dermatol Pract Concept. 2024 Oct 30;14(4):e2024241. doi: 10.5826/dpc.1404a241.
Parkinson's disease (PD) is primarily characterized by motor symptoms, but non-motor symptoms, including skin manifestations, are increasingly recognized. These remain underexplored despite their potential impact on quality of life.
This study aimed to evaluate the prevalence and clinical features of skin findings in PD patients, with a focus on identifying potential pathogenetic links between dermatological conditions and PD.
A total of 215 PD patients were included. Comprehensive dermatological examinations were performed, and demographic and clinical data were collected. Statistical analysis was conducted using SPSS 23.0, with significance set at P < 0.05.
Skin conditions were found in 92.1% of PD patients. Xerosis, seborrheic dermatitis, and hyperhidrosis were the most common findings. Pre-PD xerosis was associated with an earlier stage of PD (P = 0.001). Use of PD medications, such as levodopa/carbidopa/entacapone, was linked to a lower incidence of seborrheic dermatitis (P = 0.040). A significant correlation was also noted between rosacea and cherry angioma (P = 0.01).
Dermatological conditions are prevalent in PD and may precede its motor symptoms. Skin assessments could aid early diagnosis and management of PD, highlighting the need for further research on their pathogenetic mechanisms.
帕金森病（PD）主要以运动症状为特征，但包括皮肤表现在内的非运动症状越来越受到关注。尽管这些症状对生活质量有潜在影响，但仍未得到充分研究。
本研究旨在评估帕金森病患者皮肤表现的患病率和临床特征，重点是确定皮肤病与帕金森病之间潜在的发病机制联系。
共纳入215例帕金森病患者。进行了全面的皮肤科检查，并收集了人口统计学和临床数据。使用SPSS 23.0进行统计分析，显著性设定为P<0.05。
92.1%的帕金森病患者存在皮肤问题。皮肤干燥、脂溢性皮炎和多汗症是最常见的表现。帕金森病发病前的皮肤干燥与帕金森病的早期阶段相关（P = 0.001）。使用左旋多巴/卡比多巴/恩他卡朋等帕金森病药物与脂溢性皮炎的较低发病率相关（P = 0.040）。酒渣鼻和樱桃状血管瘤之间也存在显著相关性（P = 0.01）。
皮肤病在帕金森病中很常见，可能先于其运动症状出现。皮肤评估有助于帕金森病的早期诊断和管理，凸显了对其发病机制进行进一步研究的必要性。
