Goyal Pratika, Gupta Vinita, Aithal Sanath, Meena Dilip, Dhillon Kanwarjit Singh
Department of Dermatology, Venereology and Leprosy, Christian Medical College and Hospital, Ludhiana, Punjab, India.
Department of Dermatology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.
Dermatol Pract Concept. 2024 Oct 30;14(4):e2024218. doi: 10.5826/dpc.1404a218.
Xanthelasma palpebrarum is considered to be a cutaneous marker for cardiovascular diseases, and there is a known association with hypertension, insulin resistance, diabetes mellitus, obesity, and stroke.
Our aim was to study the association and identify the predictors of metabolic syndrome in patients with xanthelasma palpebrarum.
An observational study was conducted on 55 patients in which patients of both sexes ages 20-70 years without any other skin condition were included after written informed consent. After history and examination, blood pressure and waist circumference were measured in all the subjects. Investigations were sent for fasting blood sugar levels and serum lipid profile. The 2006 IDF Definition of metabolic syndrome was used as assessment criteria.
Among the 55 patients, metabolic syndrome was present in 23 patients (41.82%). There was a statistically significant (P<0.05) difference in the values of waist circumference (100% vs. 59.38%, P=0.0003), elevated blood pressure (82.61% vs. 9.38%, P<.0001), raised fasting blood sugar (47.83% vs. 18.75%, P=0.021), and raised triglyceride levels (56.52% vs. 25%, P=0.018) between patients with metabolic syndrome and those without. However, HDL cholesterol levels (34.78% vs. 50%, P=0.262) were comparable between groups. Also, a patient aged 41 years or more with even a single xanthelasma of more than one year's duration has a 76.1% chance of developing metabolic syndrome.
Metabolic syndrome develops in a sizeable number of xanthelasma palpebrarum patients, and this therefore gives us an opportunity for early diagnosis and intervention to prevent the development of cardiovascular complications.
睑黄瘤被认为是心血管疾病的一种皮肤标志物，并且已知与高血压、胰岛素抵抗、糖尿病、肥胖和中风有关。
我们的目的是研究睑黄瘤患者中代谢综合征的相关性并确定其预测因素。
对55例患者进行了一项观察性研究，纳入了年龄在20至70岁之间、无任何其他皮肤疾病的男女患者，并获得了书面知情同意。在进行病史询问和检查后，测量了所有受试者的血压和腰围。进行了空腹血糖水平和血脂谱的检查。采用2006年国际糖尿病联盟代谢综合征定义作为评估标准。
在55例患者中，23例（41.82%）存在代谢综合征。代谢综合征患者与无代谢综合征患者在腰围值（100%对59.38%，P = 0.0003）、血压升高（82.61%对9.38%，P <.0001）、空腹血糖升高（47.83%对18.75%，P = 0.021）和甘油三酯水平升高（56.52%对25%，P = 0.018）方面存在统计学显著差异（P < 0.05）。然而，两组之间的高密度脂蛋白胆固醇水平（34.78%对50%，P = 0.262）相当。此外，年龄41岁及以上且有一个持续时间超过一年的睑黄瘤的患者发生代谢综合征的几率为76.1%。
相当数量的睑黄瘤患者会发生代谢综合征，因此这为我们进行早期诊断和干预以预防心血管并发症的发生提供了机会。
