Chuang Tsung-Ju, Huang Chia-Luen, Lee Chien-Hsing, Hsieh Chang-Hsun, Hung Yi-Jen, Hung Chi-Feng, Liang Yao-Jen, Chen Yen-Lin, Hsia Te-Lin, Pei Dee
Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC, Taiwan, ROC; Department of Internal Medicine, Armed Forces Taichung General Hospital, Taichung, Taiwan, ROC, Taiwan, ROC.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC, Taiwan, ROC.
Arch Gerontol Geriatr. 2016 Jul-Aug;65:92-7. doi: 10.1016/j.archger.2016.03.008. Epub 2016 Mar 16.
Metabolic syndrome (MetS) is known to be correlated to future diabetes and cardiovascular disease. Due to the aging society, the increasing prevalence of MetS in the elderly is an important health issue. However, there were few studies focusing in this field. We investigated the changes of MetS components in the subgroups of the elderly.
Subjects aged above 65 years old who underwent routine health checkups in Taiwan (N=18916) were divided into three groups (young-old: ≧65 and <75, old-old: ≧75 and <85 and oldest-old ≧85). By using multiple logistic regressions, the odds ratio (OR) of subjects with abnormal MetS components to have MetS were evaluated.
For men, the systolic blood pressure (SBP) and high-density lipoprotein cholesterol increased as the age got older. On the contrary, the diastolic blood pressure and triglycerides (TG) decreased. In women, the waist circumference and SBP increased significantly from the young-old to the oldest-old groups. The highest percentage having MetS was 35% in old-old men and 62% in oldest-old women. Finally, subjects with high TG had the highest and BP had the lowest ORs for having MetS in both genders except oldest-old women.
In the elderly, the MetS and its components have different patterns not only in young-, old- and oldest-old groups but also in men and women. Moreover, among the five components, hypertension was always the most prevalent one. Finally, subjects had high TG had the highest ORs to have MetS compared to other components.
已知代谢综合征（MetS）与未来的糖尿病和心血管疾病相关。由于社会老龄化，老年人中MetS患病率的上升是一个重要的健康问题。然而，该领域的研究很少。我们调查了老年亚组中MetS各组分的变化。
在台湾接受常规健康检查的65岁以上受试者（N = 18916）被分为三组（年轻老人组：≥65岁且＜75岁，老年老人组：≥75岁且＜85岁，高龄老人组：≥85岁）。通过多元逻辑回归，评估MetS各组分异常的受试者患MetS的比值比（OR）。
对于男性，收缩压（SBP）和高密度脂蛋白胆固醇随年龄增长而升高。相反，舒张压和甘油三酯（TG）下降。在女性中，腰围和SBP从年轻老人组到高龄老人组显著增加。老年男性中患MetS的最高百分比为35%，高龄女性中为62%。最后，除高龄女性外，TG高的受试者在两性中患MetS的OR最高，而血压高的受试者OR最低。
在老年人中，MetS及其组分不仅在年轻老人组、老年老人组和高龄老人组中，而且在男性和女性中都有不同的模式。此外，在五个组分中，高血压始终是最常见的。最后，与其他组分相比，TG高的受试者患MetS的OR最高。
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