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揭示自组装肽与神经元膜之间的相互作用。

Unveiling Interactions between Self-Assembling Peptides and Neuronal Membranes.

作者信息

Fontana Federico, Donato Alice Cristina, Malik Ashish, Gelain Fabrizio

机构信息

Center for Nanomedicine and Tissue Engineering (CNTE), A.S.S.T. Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore 3, Milan 20162, Italy.

Fondazione IRCCS Casa Sollievo della Sofferenza, Unità di Ingegneria Tissutale, Viale Cappuccini 1, San Giovanni Rotondo, Foggia 71013, Italy.

出版信息

Langmuir. 2024 Dec 24;40(51):26811-26823. doi: 10.1021/acs.langmuir.4c02050. Epub 2024 Dec 9.

DOI:10.1021/acs.langmuir.4c02050
PMID:39653368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11674156/
Abstract

The use of self-assembling peptide hydrogels in the treatment of spinal cord and brain injuries, especially when combined with adult neural stem cells, has shown great potential. To advance tissue engineering, it is essential to understand the effect of mechanochemical signaling on cellular differentiation. The elucidation of the molecular interactions at the level of the neuronal membrane still represents a promising area of investigation for many drug delivery and tissue engineering applications. An innovative molecular dynamics framework has been introduced to investigate the effect of SAP fibrils with different charges on neural membrane lipid domain dynamics. Such advance enables the in silico exploration of the biomimetic properties of SAP hydrogels and other polymeric biomaterials for tissue engineering applications.

摘要

自组装肽水凝胶在脊髓和脑损伤治疗中的应用，尤其是与成体神经干细胞联合使用时，已显示出巨大潜力。为了推进组织工程，了解机械化学信号对细胞分化的影响至关重要。阐明神经元膜水平的分子相互作用对于许多药物递送和组织工程应用而言仍是一个有前景的研究领域。已引入一种创新的分子动力学框架来研究不同电荷的自组装肽原纤维对神经膜脂域动力学的影响。这种进展使得能够在计算机上探索自组装肽水凝胶和其他聚合物生物材料在组织工程应用中的仿生特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/f63d15edb89b/la4c02050_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/78a7b2d68f7c/la4c02050_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/b10bf3cdaa22/la4c02050_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/31c1bab2c575/la4c02050_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/c850893a3745/la4c02050_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/a975dff1d4df/la4c02050_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/5b8beb80a1d2/la4c02050_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/f63d15edb89b/la4c02050_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/78a7b2d68f7c/la4c02050_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/b10bf3cdaa22/la4c02050_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/31c1bab2c575/la4c02050_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/c850893a3745/la4c02050_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/a975dff1d4df/la4c02050_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/5b8beb80a1d2/la4c02050_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/11674156/f63d15edb89b/la4c02050_0007.jpg

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本文引用的文献

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Hydrogel scaffolds in the treatment of spinal cord injury: a review.水凝胶支架在脊髓损伤治疗中的应用综述
Front Neurosci. 2023 May 31;17:1211066. doi: 10.3389/fnins.2023.1211066. eCollection 2023.
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Investigating the correlation between the protein adhesion simulation and the biocompatibility of polymeric substrate for skin-tissue-engineering applications.研究蛋白质黏附模拟与用于皮肤组织工程应用的聚合基底生物相容性之间的相关性。
Phys Chem Chem Phys. 2023 Apr 12;25(15):10697-10705. doi: 10.1039/d2cp05763h.
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Modification, 3D printing process and application of sodium alginate based hydrogels in soft tissue engineering: A review.
基于海藻酸钠的水凝胶的修饰、3D 打印工艺及其在软组织工程中的应用：综述。
Int J Biol Macromol. 2023 Mar 31;232:123450. doi: 10.1016/j.ijbiomac.2023.123450. Epub 2023 Jan 26.
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Biocompatibility of Veratric Acid-Encapsulated Chitosan/Methylcellulose Hydrogel: Biological Characterization, Osteogenic Efficiency with In Silico Molecular Modeling.丁香酸包封壳聚糖/甲基纤维素水凝胶的生物相容性：生物特性表征、基于计算机分子建模的成骨效率。
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Probing mechanical properties and failure mechanisms of fibrils of self-assembling peptides.探究自组装肽原纤维的力学性能和失效机制。
Nanoscale Adv. 2019 Dec 23;2(1):190-198. doi: 10.1039/c9na00621d. eCollection 2020 Jan 22.
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Regulation of membrane protein structure and function by their lipid nano-environment.膜蛋白结构和功能的脂质纳米环境调节。
Nat Rev Mol Cell Biol. 2023 Feb;24(2):107-122. doi: 10.1038/s41580-022-00524-4. Epub 2022 Sep 2.
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Unraveling membrane properties at the organelle-level with LipidDyn.利用LipidDyn在细胞器水平解析膜特性。
Comput Struct Biotechnol J. 2022 Jun 30;20:3604-3614. doi: 10.1016/j.csbj.2022.06.054. eCollection 2022.
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The role of mechanics in axonal stability and development.力学在轴突稳定性和发育中的作用。
Semin Cell Dev Biol. 2023 May 15;140:22-34. doi: 10.1016/j.semcdb.2022.06.006. Epub 2022 Jun 30.
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