Cai Manqi, Chen Liji, Wang Tao, Liang Yinru, Zhao Jie, Zhang Xiaomin, Li Ziyi, Wu Hongfu
Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.
Department of Surgery, The Third Hospital of Guangdong Medical University (Longjiang Hospital of Shunde District), Foshan, China.
Front Neurosci. 2023 May 31;17:1211066. doi: 10.3389/fnins.2023.1211066. eCollection 2023.
Spinal cord injury (SCI) is a disease of the central nervous system often caused by accidents, and its prognosis is unsatisfactory, with long-term adverse effects on patients' lives. The key to its treatment lies in the improvement of the microenvironment at the injury and the reconstruction of axons, and tissue repair is a promising therapeutic strategy. Hydrogel is a three-dimensional mesh structure with high water content, which has the advantages of biocompatibility, degradability, and adjustability, and can be used to fill pathological defects by injectable flowing hydrophilic material to accurately adapt to the size and shape of the injury. Hydrogels mimic the natural extracellular matrix for cell colonization, guide axon extension, and act as a biological scaffold, which can be used as an excellent carrier to participate in the treatment of SCI. The addition of different materials to make composite hydrogel scaffolds can further enhance their performance in all aspects. In this paper, we introduce several typical composite hydrogels and review the research progress of hydrogel for SCI to provide a reference for the clinical application of hydrogel therapy for SCI.
脊髓损伤(SCI)是一种中枢神经系统疾病,常由意外事故引起,其预后并不理想,会对患者生活产生长期不良影响。其治疗的关键在于改善损伤部位的微环境和轴突的重建,组织修复是一种很有前景的治疗策略。水凝胶是一种具有高含水量的三维网状结构,具有生物相容性、可降解性和可调节性等优点,可通过可注射流动的亲水性材料用于填充病理缺损,以精确适应损伤的大小和形状。水凝胶模拟天然细胞外基质用于细胞定植、引导轴突延伸,并作为生物支架,可作为一种优异的载体参与脊髓损伤的治疗。添加不同材料制成复合水凝胶支架可进一步增强其各方面性能。本文介绍了几种典型的复合水凝胶,并综述了水凝胶治疗脊髓损伤的研究进展,为水凝胶疗法在脊髓损伤临床应用中提供参考。