Mesas Cristina, Moreno Javier, Doello Kevin, Peña Mercedes, López-Romero Juan M, Prados Jose, Melguizo Consolación
Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, Granada, Spain.
Instituto de Investigación Biosanitaria de Granada, (ibs.GRANADA), Granada, Spain.
Biofactors. 2025 Jan-Feb;51(1):e2148. doi: 10.1002/biof.2148. Epub 2024 Dec 9.
Stem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells, are responsible for tumor metastasis and resistance to chemo- and radiotherapy and to tumor relapse. Interestingly, all stem cells have cannabinoid receptors, such as cannabidiol (CBD), that perform biological functions. The aim of this systematic review was to analyze the effect of CBD on both somatic stem cells (SSCs) and CSCs. Of the 276 articles analyzed, 38 were selected according to the inclusion and exclusion criteria. A total of 27 studied the effect of CBD on SSCs, finding that 44% focused on CBD differentiation effect and 56% on its protective activity. On the other hand, 11 articles looked at the effect of CBD on CSCs, including glioblastoma (64%), lung cancer (27%), and breast cancer (only one article). Our results showed that CBD exerted a differentiating and protective effect on SCCs. In addition, this molecule demonstrated an antiproliferative effect on some CSCs, although most of the analyses were performed in vitro. Therefore, although in vivo studies should be necessary to justify its clinical use, CBD and its receptors could be a specific target to act on both SSCs and CSCs.
干细胞在人体组织再生和修复中发挥着关键作用。此外，癌症干细胞（CSCs）作为癌细胞的亚群，具有与正常干细胞相似的特征，它们负责肿瘤转移、对化疗和放疗的抗性以及肿瘤复发。有趣的是，所有干细胞都有大麻素受体，如大麻二酚（CBD），这些受体发挥着生物学功能。本系统综述的目的是分析CBD对体细胞干细胞（SSCs）和癌症干细胞的影响。在分析的276篇文章中，根据纳入和排除标准选择了38篇。共有27篇研究了CBD对SSCs的影响，发现44%关注CBD的分化作用，56%关注其保护活性。另一方面，11篇文章研究了CBD对CSCs的影响，包括胶质母细胞瘤（64%）、肺癌（27%）和乳腺癌（仅一篇文章）。我们的结果表明，CBD对SSCs具有分化和保护作用。此外，该分子对某些CSCs表现出抗增殖作用，尽管大多数分析是在体外进行的。因此，虽然需要进行体内研究来证明其临床应用的合理性，但CBD及其受体可能是作用于SSCs和CSCs的一个特定靶点。
