Maratka Z, Nedbal J, Kociánová J, Havelka J, Kudrmann J, Hendl J
Gut. 1985 Jan;26(1):43-9. doi: 10.1136/gut.26.1.43.
The incidence of colorectal cancer was studied by the actuarial method in 959 patients with idiopathic proctocolitis seen from 1942 to 1981. Forty five per cent had rectal, 23% left-sided, and 32% total involvement of the colon. Six cancers were found: one in the rectal, one in the left-sided, and four in the total form of the disease. The risk of cancer per patient year in total colitis was zero per 2151 patient years in the first decade, 1/462 in the second decade, 1/315 in the third decade, and 1/75 in the fourth decade. The cumulative risk of developing cancer was zero at 10 years of duration of the disease, approximately 5% at 20 years, 15% at 30 years, and 20% at 35 years. This increase in risk of cancer is less than reported in some other series. Geographical differences in the incidence of cancer in proctocolitis could influence the risk and therefore also the long-term management of patients with proctocolitis in different geographical areas.
采用精算方法对1942年至1981年间诊治的959例特发性直肠结肠炎患者的结直肠癌发病率进行了研究。45%的患者病变累及直肠，23%累及左半结肠，32%累及整个结肠。共发现6例癌症：1例发生在直肠，1例发生在左半结肠，4例发生在全结肠型疾病。全结肠炎患者每年患癌风险在第一个十年每2151患者年为零，第二个十年为1/462，第三个十年为1/315，第四个十年为1/75。患病10年时患癌累积风险为零，20年时约为5%，30年时为15%，35年时为20%。这种患癌风险的增加低于其他一些系列报道。直肠结肠炎癌症发病率的地域差异可能会影响风险，因此也会影响不同地理区域直肠结肠炎患者的长期管理。
