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肠道病毒组在雌激素缺乏诱导的骨质疏松症进展中的改变及密切相互作用

Alterations of gut virome with close interaction in the progression of estrogen deficiency-induced osteoporosis.

作者信息

Chen Yueqi, Yang Chuan, Deng Zihan, Xiang Tingwen, Tan Jiulin, Xu Jianzhong, Sun Dong, Luo Fei

机构信息

Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.

Department of Orthopedics, Chinese PLA 76th Army Corps Hospital, Xining, People's Republic of China.

出版信息

Gut Microbes. 2024 Jan-Dec;16(1):2437250. doi: 10.1080/19490976.2024.2437250. Epub 2024 Dec 9.

DOI:10.1080/19490976.2024.2437250
PMID:39653684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11633233/
Abstract

Previous research has established a link between gut microbiota and osteoporosis (OP) advancement. However, there remains a limited understanding of the crucial contribution of the gut virome in the onset and progression of OP. We employed metagenomic shotgun sequencing and gut virome sequencing to process the ovariectomy (OVX)-induced OP murine model, which revealed significant disparities in bacteriome and virome compositions between subjects with OP and healthy controls. One hundred and seventy-four altered viral strains were identified to participate in the multifaceted regulation of bone loss, involving immune modulation, microbial metabolic activity, and intricate host-virus dynamics. Our findings suggested that the gut virome may influence bone metabolism, potentially altering the balance of bone-modulating compounds like short-chain fatty acids. This comprehensive analysis of the gut virome in OP highlighted the diagnostic potential of combined gut viral and bacterial biomarkers for OP.

摘要

先前的研究已经确立了肠道微生物群与骨质疏松症（OP）进展之间的联系。然而，对于肠道病毒组在OP的发生和发展中的关键作用，人们的了解仍然有限。我们采用宏基因组鸟枪法测序和肠道病毒组测序来处理卵巢切除（OVX）诱导的OP小鼠模型，结果显示OP患者与健康对照者之间的细菌组和病毒组组成存在显著差异。共鉴定出174种改变的病毒株参与了骨质流失的多方面调节，涉及免疫调节、微生物代谢活性以及复杂的宿主-病毒相互作用。我们的研究结果表明，肠道病毒组可能会影响骨代谢，潜在地改变短链脂肪酸等骨调节化合物的平衡。这项对OP患者肠道病毒组的综合分析突出了肠道病毒和细菌生物标志物联合用于OP诊断的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/2ba289a650a8/KGMI_A_2437250_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/c84b835ec34c/KGMI_A_2437250_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/d38e2415a2bd/KGMI_A_2437250_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/e21f6be47475/KGMI_A_2437250_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/d4ce46b037cc/KGMI_A_2437250_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/e99018b87b3e/KGMI_A_2437250_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/5c5d06675403/KGMI_A_2437250_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/2ba289a650a8/KGMI_A_2437250_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/c84b835ec34c/KGMI_A_2437250_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/d38e2415a2bd/KGMI_A_2437250_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/e21f6be47475/KGMI_A_2437250_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/d4ce46b037cc/KGMI_A_2437250_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/e99018b87b3e/KGMI_A_2437250_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/5c5d06675403/KGMI_A_2437250_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73b4/11633233/2ba289a650a8/KGMI_A_2437250_F0007_OC.jpg

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