Zhang Ziyi, Zhao Lanlan, Wu Jiacheng, Pan Yingmiao, Zhao Guoping, Li Ziyun, Zhang Lei
Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250000, China.
State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266000, China.
Microorganisms. 2023 Oct 17;11(10):2580. doi: 10.3390/microorganisms11102580.
has been used as a probiotic for decades to treat a wide range of illnesses, and has been found to have specific advantages in the treatment of a number of ailments. We reviewed the potential therapeutic effects and mechanisms of in various diseases based on PubMed and the Web of Science databases. We obtained the information of 149 from NCBI (as of 14 February 2023), and reviewed their comprehensive metadata, including information about the plasmids they contain. This review provides a basic characterization of different and some of their potential therapeutic properties for various ailments. Although the mechanisms are not fully understood yet, it is hoped that they may provide some evidence for future studies. Furthermore, the antibiotic resistance of the various strains of is not clear, and more complete and in-depth studies are needed. In summary, presents significant research potential for the treatment or prevention of disease; however, more proof is required to justify its therapeutic application. An additional study on the antibiotic resistance genes it contains is also needed to reduce the antimicrobial resistance dissemination.
几十年来，它一直被用作益生菌来治疗多种疾病，并且已发现在治疗多种疾病方面具有特定优势。我们基于PubMed和科学网数据库综述了它在各种疾病中的潜在治疗作用和机制。我们从NCBI获取了149种它的信息（截至2023年2月14日），并综述了它们的全面元数据，包括它们所含质粒的信息。本综述提供了不同的它的基本特征以及它们对各种疾病的一些潜在治疗特性。尽管其机制尚未完全明了，但希望能为未来研究提供一些证据。此外，不同菌株的它的抗生素耐药性尚不清楚，需要更全面和深入的研究。总之，它在疾病治疗或预防方面具有显著的研究潜力；然而，需要更多证据来证明其治疗应用的合理性。还需要对其所含抗生素耐药基因进行额外研究，以减少抗菌药物耐药性的传播。
