Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Aging Dis. 2023 Dec 1;14(6):2015-2027. doi: 10.14336/AD.2023.0325.
Akkermansia muciniphila (A. muciniphila) is an anaerobic bacterium that widely colonizes the mucus layer of the human and animal gut. The role of this symbiotic bacterium in host metabolism, inflammation, and cancer immunotherapy has been extensively investigated over the past 20 years. Recently, a growing number of studies have revealed a link between A. muciniphila, and aging and aging-related diseases (ARDs). Research in this area is gradually shifting from correlation analysis to exploration of causal relationships. Here, we systematically reviewed the association of A. muciniphila with aging and ARDs (including vascular degeneration, neurodegenerative diseases, osteoporosis, chronic kidney disease, and type 2 diabetes). Furthermore, we summarize the potential mechanisms of action of A. muciniphila and offer perspectives for future studies.
黏蛋白阿克曼菌（Akkermansia muciniphila）是一种广泛定植于人和动物肠道黏液层的厌氧细菌。在过去的 20 年中，人们对这种共生菌在宿主代谢、炎症和癌症免疫治疗中的作用进行了广泛的研究。最近，越来越多的研究揭示了黏蛋白阿克曼菌与衰老和与衰老相关的疾病（ARDs）之间的联系。该领域的研究正在逐渐从相关性分析转向对因果关系的探索。在这里，我们系统地综述了黏蛋白阿克曼菌与衰老和 ARDs（包括血管退行性疾病、神经退行性疾病、骨质疏松症、慢性肾脏病和 2 型糖尿病）的关联。此外，我们总结了黏蛋白阿克曼菌的潜在作用机制，并为未来的研究提供了一些观点。
