Cao Zhenghua, Zhao Shengkun, Wu Tong, Sun Feng, Hu Shaodan, Shi Li
Graduate School, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Geriatric Department, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, China.
Front Microbiol. 2024 Nov 25;15:1416651. doi: 10.3389/fmicb.2024.1416651. eCollection 2024.
The gut microbiota and its metabolites exert a significant influence on COPD, yet the underlying mechanisms remain elusive. We aim to holistically evaluate the role and mechanisms of the gut microbiota and its metabolites in COPD through network pharmacology and Mendelian randomization approaches.
Employing network pharmacology, we identified the gut microbiota and its metabolites' impact on COPD-related targets, elucidating the complex network mechanisms involving the gut microbiota, its metabolites, targets, and signaling pathways in relation to COPD. Further, promising gut microbiota metabolites and microbiota were pinpointed, with their causal relationships inferred through Mendelian randomization.
A complex biological network was constructed, comprising 39 gut microbiota, 20 signaling pathways, 19 targets, and 23 metabolites associated with COPD. emerged as a potentially promising metabolite for COPD treatment, with Mendelian randomization analysis revealing a causal relationship with COPD.
This study illuminates the intricate associations between the gut microbiota, its metabolites, and COPD. may represent a novel avenue for COPD treatment. These findings could aid in identifying individuals at high risk for COPD, offering insights into early prevention and treatment strategies.
肠道微生物群及其代谢产物对慢性阻塞性肺疾病（COPD）有重大影响，但其潜在机制仍不清楚。我们旨在通过网络药理学和孟德尔随机化方法全面评估肠道微生物群及其代谢产物在COPD中的作用和机制。
利用网络药理学，我们确定了肠道微生物群及其代谢产物对COPD相关靶点的影响，阐明了涉及肠道微生物群、其代谢产物、靶点以及与COPD相关的信号通路的复杂网络机制。此外，还确定了有前景的肠道微生物群代谢产物和微生物群，并通过孟德尔随机化推断它们之间的因果关系。
构建了一个复杂的生物网络，包括39种肠道微生物群、20条信号通路、19个靶点和23种与COPD相关的代谢产物。[此处原文未明确指出具体是什么物质“emerged as a potentially promising metabolite for COPD treatment”，暂按原文翻译]作为一种潜在的有前景的COPD治疗代谢产物出现，孟德尔随机化分析揭示了其与COPD的因果关系。
本研究阐明了肠道微生物群、其代谢产物与COPD之间的复杂关联。[此处原文未明确指出具体是什么物质“may represent a novel avenue for COPD treatment”，暂按原文翻译]可能代表了一种COPD治疗的新途径。这些发现有助于识别COPD高危个体，为早期预防和治疗策略提供见解。
