Søby Jacob Hartmann, Schmidt Morten, Nissen Louise, Ejlersen June Anita, Gormsen Lars Christian, Pedersen Kasper Tholstrup, Holdgaard Paw Christian, Mortensen Jesper, Rasmussen Laust Dupont, Ravn Søren, Horvat Rika, Winther Simon, Böttcher Morten
University Clinic for Cardiovascular Research, Department of Cardiology, Gødstrup Hospital, Herning, Denmark.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
Clin Epidemiol. 2024 Dec 5;16:849-863. doi: 10.2147/CLEP.S469538. eCollection 2024.
Myocardial perfusion imaging (MPI) procedures from single photon emission computed tomography and positron emission tomography imaging have been registered in the Western Denmark Heart Registry (WDHR) since 2017 as a sub-registry (WDHR-MPI). The aim was to review the content, quality, and research potential of the WDHR-MPI and assess the completeness and validity of its key variables.
Using the Danish National Patient Registry (DNPR) as a reference, we calculated the completeness of procedure registration as the proportion of procedures registered in the WDHR-MPI from 2017 to 2021. We defined completeness of variable registration as the proportion of non-missing values for a given variable and examined it for 38 key variables. We assessed validity by estimating the positive predictive values (PPV) and negative predictive values (NPV) with 95% confidence intervals (CI) for 26 selected key variables using corresponding extracted information from 300 randomly selected patient records.
We identified 19,084 procedures in 17,871 patients from all seven cardiac centers performing nuclear cardiology procedures in the WDHR uptake area. The registry accumulated 4000-6000 procedures each year from 2019 to 2021. The overall completeness of procedure registration was 72% (95% CI 72-73), increasing from 14% (95% CI 13-15) in 2017 to 98% (95% CI 98-98) in 2021. The mean completeness of variable registration was 89%. The validity of entered data was high, with an overall PPV for the selected key variables of 95% (95% CI 94-95) and NPV of 94% (95% CI 93-96).
The WDHR-MPI is one of the largest systematic MPI cohorts. The overall high completeness and validity of the data support its potential for cardio-epidemiological research.
自2017年起，单光子发射计算机断层扫描和正电子发射断层扫描成像的心肌灌注成像（MPI）程序已作为一个子登记处（WDHR-MPI）登记在丹麦西部心脏登记处（WDHR）中。目的是审查WDHR-MPI的内容、质量和研究潜力，并评估其关键变量的完整性和有效性。
以丹麦国家患者登记处（DNPR）为参考，我们计算了程序登记的完整性，即2017年至2021年在WDHR-MPI中登记的程序比例。我们将变量登记的完整性定义为给定变量的非缺失值比例，并对38个关键变量进行了检查。我们通过使用从300份随机选择的患者记录中提取的相应信息，估计26个选定关键变量的阳性预测值（PPV）和阴性预测值（NPV）及其95%置信区间（CI）来评估有效性。
我们在WDHR接收区域内进行核心脏病学程序的所有七个心脏中心的17871名患者中识别出19084个程序。该登记处从2019年到2021年每年积累4000 - 6000个程序。程序登记的总体完整性为72%（95%CI 72 - 73），从2017年的14%（95%CI 13 - 15）增加到2021年的98%（95%CI 98 - 98）。变量登记的平均完整性为89%。输入数据的有效性很高，选定关键变量的总体PPV为95%（95%CI 94 - 95），NPV为94%（95%CI 93 - 96）。
WDHR-MPI是最大的系统性MPI队列之一。数据总体上较高的完整性和有效性支持其在心脏流行病学研究中的潜力。
