Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Ste. A047N, Los Angeles, CA, 90048, USA.
Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
J Nucl Cardiol. 2020 Jun;27(3):1010-1021. doi: 10.1007/s12350-018-1326-4. Epub 2018 Jun 19.
We aim to establish a multicenter registry collecting clinical, imaging, and follow-up data for patients who undergo myocardial perfusion imaging (MPI) with the latest generation SPECT scanners.
REFINE SPECT (REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT) uses a collaborative design with multicenter contribution of clinical data and images into a comprehensive clinical-imaging database. All images are processed by quantitative software. Over 290 individual imaging variables are automatically extracted from each image dataset and merged with clinical variables. In the prognostic cohort, patient follow-up is performed for major adverse cardiac events. In the diagnostic cohort (patients with correlating invasive angiography), angiography and revascularization results within 6 months are obtained.
To date, collected prognostic data include scans from 20,418 patients in 5 centers (57% male, 64.0 ± 12.1 years) who underwent exercise (48%) or pharmacologic stress (52%). Diagnostic data include 2079 patients in 9 centers (67% male, 64.7 ± 11.2 years) who underwent exercise (39%) or pharmacologic stress (61%).
The REFINE SPECT registry will provide a resource for collaborative projects related to the latest generation SPECT-MPI. It will aid in the development of new artificial intelligence tools for automated diagnosis and prediction of prognostic outcomes.
本研究旨在建立一个多中心注册研究，以收集接受最新一代单光子发射计算机断层扫描（SPECT）心肌灌注成像（MPI）的患者的临床、影像和随访数据。
REFINE SPECT（使用新一代 SPECT 快速心肌灌注成像注册研究）采用协作设计，多中心贡献临床数据和图像到综合临床影像数据库。所有图像均由定量软件进行处理。从每个图像数据集自动提取超过 290 个个体影像变量，并与临床变量合并。在预后队列中，对主要不良心脏事件进行患者随访。在诊断队列（与相关侵入性血管造影的患者）中，在 6 个月内获得血管造影和血运重建结果。
迄今为止，已收集了 5 个中心的 20418 例患者的预后数据（57%为男性，64.0±12.1 岁），这些患者接受了运动（48%）或药物负荷（52%）检查。诊断数据包括 9 个中心的 2079 例患者（67%为男性，64.7±11.2 岁），这些患者接受了运动（39%）或药物负荷（61%）检查。
REFINE SPECT 注册研究将为与最新一代 SPECT-MPI 相关的合作项目提供资源。它将有助于开发新的人工智能工具，用于自动诊断和预测预后结果。
