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甲型流感病毒继发曲霉感染“治疗失败”的病例报告及文献综述

Case Report and Literature Review of "Treatment Failure" of Aspergillus Infection Secondary to Influenza a Virus.

作者信息

Teng Peikun, Liu Yuzhan, Zhang Xingyu, Luan Nianxu, Han Xiudi, Liu Xuedong

机构信息

Department of Respiratory and Critical Care Medicine, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266000, People's Republic of China.

Human Resources Department, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266000, People's Republic of China.

出版信息

J Inflamm Res. 2024 Dec 4;17:10305-10311. doi: 10.2147/JIR.S496441. eCollection 2024.

DOI:10.2147/JIR.S496441
PMID:39654861
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11625640/
Abstract

PURPOSE

Increased clinical manifestations combined with increased lung imaging findings during antifungal therapy are often misjudged as failure of antifungal therapy, and should be vigilant against immune reconstitution inflammatory syndrome.

CASE

We describes a case of invasive pulmonary Aspergillus infection after Influenza A Virus (IAV). After active antifungal therapy, the patient's clinical symptoms continued to worsen, imaging lesions continued to progress, laboratory indicators improved, and immune reconstitution inflammatory syndrome was considered.

CONCLUSION

The clinical characteristics and treatment process of this case were summarized, and related literature search was carried out, in order to provide a new perspective for the treatment failure of fungal infection in the future, and to avoid the random change of antifungal drugs, which may lead to the increase of drug resistance.

摘要

目的

抗真菌治疗期间临床表现加重并伴有肺部影像学表现增多常被误诊为抗真菌治疗失败，应警惕免疫重建炎症综合征。

病例

我们描述了1例甲型流感病毒（IAV）感染后侵袭性肺曲霉感染的病例。积极抗真菌治疗后，患者临床症状持续加重，影像学病灶持续进展，实验室指标改善，考虑为免疫重建炎症综合征。

结论

总结该病例的临床特点及治疗过程，并进行相关文献检索，以期为今后真菌感染治疗失败提供新的视角，避免因随意更换抗真菌药物而导致耐药性增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/d64378f506f2/JIR-17-10305-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/14c97b464ef0/JIR-17-10305-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/474f015b245d/JIR-17-10305-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/be3fba926c40/JIR-17-10305-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/0827ae084863/JIR-17-10305-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/4e5214b098ef/JIR-17-10305-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/d64378f506f2/JIR-17-10305-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/14c97b464ef0/JIR-17-10305-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/474f015b245d/JIR-17-10305-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/be3fba926c40/JIR-17-10305-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/0827ae084863/JIR-17-10305-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/4e5214b098ef/JIR-17-10305-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e674/11625640/d64378f506f2/JIR-17-10305-g0006.jpg

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Indian J Tuberc. 2024 Jul;71(3):291-296. doi: 10.1016/j.ijtb.2023.05.015. Epub 2023 May 29.
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J Fungi (Basel). 2024 Mar 27;10(4):251. doi: 10.3390/jof10040251.
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Global incidence and mortality of severe fungal disease.全球严重真菌感染的发病率和死亡率。
Lancet Infect Dis. 2024 Jul;24(7):e428-e438. doi: 10.1016/S1473-3099(23)00692-8. Epub 2024 Jan 12.
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