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肿瘤免疫中的骨钙素-1：通过巨噬细胞发挥作用。

Stanniocalcin-1 in tumor immunity: acts via macrophages.

作者信息

Wang Lele, Wang Jianjun, Qiang Weijie, Ge Weihong

机构信息

Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

出版信息

Front Immunol. 2024 Nov 25;15:1510182. doi: 10.3389/fimmu.2024.1510182. eCollection 2024.

DOI:10.3389/fimmu.2024.1510182
PMID:39654892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11625730/
Abstract

Tumor immune escape has become a research hotspot in the field of cancer immunotherapy. Tumor-associated macrophages (TAMs) are the key component of tumor microenvironment, which play a pivotal role in tumor immune escape by regulating the immunity checkpoints, inhibiting the activity of T lymphocytes and natural killer (NK) cells, and modulating proportion of different T cells. Stanniocalcin-1(STC1)is ubiquitously expressed in human body, which is proven to involve with tumor progression and clinical prognosis. Recently, STC1 is implicated in tumor microenvironment as a phagocytosis checkpoint, as well as regulates the immunity via macrophages. In the review, we discussed the role of STC1 and TAMs in tumor immunity and their crosstalk, hoping to provide references for the research of STC1 in tumor immunotherapy.

摘要

肿瘤免疫逃逸已成为癌症免疫治疗领域的研究热点。肿瘤相关巨噬细胞（TAM）是肿瘤微环境的关键组成部分，通过调节免疫检查点、抑制T淋巴细胞和自然杀伤（NK）细胞的活性以及调节不同T细胞的比例，在肿瘤免疫逃逸中发挥关键作用。1型鲟钙蛋白（STC1）在人体中广泛表达，已被证明与肿瘤进展和临床预后有关。最近，STC1作为一种吞噬作用检查点参与肿瘤微环境，并且通过巨噬细胞调节免疫。在这篇综述中，我们讨论了STC1和TAM在肿瘤免疫中的作用及其相互作用，希望为STC1在肿瘤免疫治疗中的研究提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046f/11625730/72f967f1bab2/fimmu-15-1510182-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046f/11625730/fa7a021fd0c4/fimmu-15-1510182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046f/11625730/166f8a94ebc9/fimmu-15-1510182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046f/11625730/72f967f1bab2/fimmu-15-1510182-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046f/11625730/fa7a021fd0c4/fimmu-15-1510182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046f/11625730/166f8a94ebc9/fimmu-15-1510182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046f/11625730/72f967f1bab2/fimmu-15-1510182-g003.jpg

相似文献

[1]
Stanniocalcin-1 in tumor immunity: acts via macrophages.

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[2]
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本文引用的文献

[1]
Macrophage diversity in cancer dissemination and metastasis.

Cell Mol Immunol. 2024-11

[2]
Stanniocalcin Protein Expression in Female Reproductive Organs: Literature Review and Public Cancer Database Analysis.

Endocrinology. 2024-8-27

[3]
A detailed insight into macrophages' role in shaping lung carcinogenesis.

Life Sci. 2024-9-1

[4]
STC1 competitively binding βPIX enhances melanoma progression via YAP nuclear translocation and M2 macrophage recruitment through the YAP/CCL2/VEGFA/AKT feedback loop.

Pharmacol Res. 2024-6

[5]
MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria.

Stem Cell Res Ther. 2024-5-1

[6]
Understanding and overcoming resistance to immunotherapy in genitourinary cancers.

Cancer Biol Ther. 2024-12-31

[7]
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2024

[8]
Exosome-transmitted podoplanin promotes tumor-associated macrophage-mediated immune tolerance in glioblastoma.

CNS Neurosci Ther. 2024-3

[9]
Advanced insights on tumor-associated macrophages revealed by single-cell RNA sequencing: The intratumor heterogeneity, functional phenotypes, and cellular interactions.

Cancer Lett. 2024-3-1

[10]
Tumor-associated macrophages: an effective player of the tumor microenvironment.

Front Immunol. 2023

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