Farah Amir, Tatakis Anna, Obeid Amir, Sayida Sa'd
Surgery, Medical College of Wisconsin, Milwaukee, USA.
General Surgery, Medical College of Wisconsin, Milwaukee, USA.
Cureus. 2024 Nov 9;16(11):e73331. doi: 10.7759/cureus.73331. eCollection 2024 Nov.
Appendicitis remains a common cause of acute abdominal pain, particularly challenging to manage in elderly patients due to age-related declines in physiological reserve and the presence of comorbidities. While appendectomy has traditionally been the standard treatment, nonoperative management (NOM) using antibiotics has emerged as a potential alternative for elderly patients, especially those considered frail or at high surgical risk. This review explores the efficacy and outcomes of NOM compared to surgery in this population, with a focus on recurrence rates, postoperative complications, and the impact of frailty on treatment decisions. Recent studies highlight both the benefits and limitations of NOM. While it can effectively manage uncomplicated appendicitis in the short term, recurrence rates are significantly higher in elderly patients, often necessitating delayed surgery, which can lead to worse outcomes. Research also shows that frail patients face elevated risks of complications, including mortality, whether treated surgically or nonoperatively. The review underscores the importance of careful patient selection, close monitoring, and individualized treatment approaches when considering NOM for elderly patients with appendicitis. Long-term risks such as recurrence, antibiotic resistance, and complications further complicate the decision-making process.
阑尾炎仍然是急性腹痛的常见原因,由于生理储备的年龄相关下降和合并症的存在,在老年患者中治疗尤其具有挑战性。虽然传统上阑尾切除术一直是标准治疗方法,但使用抗生素的非手术治疗(NOM)已成为老年患者的一种潜在替代方案,尤其是那些被认为身体虚弱或手术风险高的患者。本综述探讨了在该人群中NOM与手术相比的疗效和结果,重点关注复发率、术后并发症以及身体虚弱对治疗决策的影响。最近的研究突出了NOM的益处和局限性。虽然它可以在短期内有效治疗非复杂性阑尾炎,但老年患者的复发率明显更高,常常需要延迟手术,这可能导致更差的结果。研究还表明,无论接受手术治疗还是非手术治疗,身体虚弱的患者面临的并发症风险都会升高,包括死亡风险。该综述强调了在考虑为老年阑尾炎患者进行NOM时,仔细选择患者、密切监测和个体化治疗方法的重要性。复发、抗生素耐药性和并发症等长期风险使决策过程更加复杂。