Azad Hossein, Hotrmati Ahmad, Sarkeshikian Seyed S, Mohammadbeigi Abolfazl, Razavinia Fatemehsadat, Eshaghi Far Mohammad, Pezeshgi Modarres Mehdi
Clinical Research of Development Unit, Shahid Beheshti Hospital Qom University of Medical Sciences Qom Iran.
Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Department of Internal Medicine, School of Medicine Tehran University of Medical Sciences Tehran Iran.
JGH Open. 2024 Dec 8;8(12):e70046. doi: 10.1002/jgh3.70046. eCollection 2024 Dec.
The treatment for is considered to be a combination of several strict regimens, with patients' dissatisfaction and poor compliance. Probiotics are effective in patients' antibiotic regimens. This study investigated the efficacy of the Pyloshot probiotic in combination with standard four-drug therapy in patients with infection.
This is an interventional study. The study population consisted of patients with infection who were selected using the convenience sampling method and were randomly divided into two groups: (i) A or standard four-drug therapy (amoxicillin-clarithromycin-bismuth-pantoprazole) plus two placebo capsules (80 cases). (ii) B or Pyloshot group (standard four-drug therapy plus 2 Pyloshot probiotic capsules) (90 cases). Patients were followed up for 1 month after treatment completion. Eradication of was also assessed using the stool antigen test. Data were analyzed using SPSS (v.26) statistical software.
Based on the results from the present study, the number of negative stool antigen tests in group A was less than that in group B, and no statistically significant relationship was found between eradication (based on stool antigen test) and the studied groups ( = 0.20). There was a statistically significant relationship between vomiting ( = 0.03), diarrhea ( = 0.04), constipation ( = 0.01), and headache ( = 0.04); vomiting and constipation were most frequent in the control group.
Based on the results of the present study, there was no significant difference between the effectiveness of treatment with Pyloshot probiotic and the standard four-drug therapy in patients with infection. However, the incidence of side effects was lower in the group treated with Pyloshot.
[疾病名称]的治疗被认为是几种严格治疗方案的联合，但患者满意度低且依从性差。益生菌在患者抗生素治疗方案中有效。本研究调查了Pyloshot益生菌联合标准四联疗法治疗[疾病名称]感染患者的疗效。
这是一项干预性研究。研究人群包括采用便利抽样法选取的[疾病名称]感染患者，随机分为两组：（i）A组或标准四联疗法（阿莫西林 - 克拉霉素 - 铋剂 - 泮托拉唑）加两粒安慰剂胶囊（80例）。（ii）B组或Pyloshot组（标准四联疗法加2粒Pyloshot益生菌胶囊）（90例）。治疗完成后对患者进行1个月的随访。还使用粪便抗原检测评估[疾病名称]的根除情况。数据采用SPSS（v.26）统计软件进行分析。
根据本研究结果，A组粪便抗原检测阴性的数量少于B组，且（基于粪便抗原检测的）[疾病名称]根除情况与研究组之间未发现统计学上的显著关系（P = 0.20）。呕吐（P = 0.03）、腹泻（P = 0.04）、便秘（P = 0.01）和头痛（P = 0.04）之间存在统计学上的显著关系；对照组呕吐和便秘最为常见。
根据本研究结果，Pyloshot益生菌治疗与标准四联疗法治疗[疾病名称]感染患者的有效性之间无显著差异。然而，Pyloshot治疗组的副作用发生率较低。
