Saito I, Ito K, Saruta T
J Am Geriatr Soc. 1985 Jan;33(1):19-22. doi: 10.1111/j.1532-5415.1985.tb02854.x.
To better define the effect of age on blood pressure in patients with hyperthyroidism, the blood pressures of 321 patients with hyperthyroidism were compared with those of 324 euthyroid controls. Subjects were divided into four age groups by decade from 20 to 59 years. The systolic, but not diastolic, blood pressure in the patients with hyperthyroidism was significantly higher in all age groups. Among the euthyroid controls, the systolic blood pressure increased with age. However, no age-related increase was apparent among the hyperthyroid patients because of the relatively high systolic blood pressure in young patients. Effective antithyroid treatment reduced the systolic blood pressure significantly in hyperthyroid patients. The reduction of systolic blood pressure was greater in the younger hyperthyroid patients than that in the older ones, so that an age-related increase in systolic blood pressure was present after a euthyroid state had been achieved. These results provide evidence against the report that in hyperthyroidism, hypertension tends to occur in older patients, and suggest that the effect of excessive thyroid hormone on the systolic blood pressure may differ according to age.
为了更好地明确年龄对甲状腺功能亢进患者血压的影响，将321例甲状腺功能亢进患者的血压与324例甲状腺功能正常的对照者的血压进行了比较。受试者按年龄段分为20至59岁的四个年龄组。在所有年龄组中，甲状腺功能亢进患者的收缩压显著高于对照组，但舒张压并非如此。在甲状腺功能正常的对照者中，收缩压随年龄增长而升高。然而，在甲状腺功能亢进患者中，由于年轻患者的收缩压相对较高，未观察到与年龄相关的升高。有效的抗甲状腺治疗可使甲状腺功能亢进患者的收缩压显著降低。年轻的甲状腺功能亢进患者收缩压的降低幅度大于年长患者，因此在达到甲状腺功能正常状态后，收缩压出现了与年龄相关的升高。这些结果提供了证据，反驳了甲状腺功能亢进时高血压倾向于在老年患者中发生的报道，并表明过量甲状腺激素对收缩压的影响可能因年龄而异。
