肺纤维化患者的肺癌：特征与预后

Lung cancer in patients with pulmonary fibrosis: characteristics features and prognosis.

作者信息

Kara Sibel, Mogulkoc Nesrin, Kirkil Gamze, Cetinkaya Erdogan, Ozbudak Omer, Kilic Talat, Demirci Ucsular Fatma, Demirkol Baris, Duman Dildar, Karadeniz Gulistan, Koksal Nurhan, Soyler Yasemin, Gunbatar Hulya, Oruc Ozlem, Tapan Utku, Akbas Kubra Elif, Unat Omer Selim

机构信息

University of Health Sciences, Adana City Education and Research Hospital, Chest Diseases Clinic, Adana.

Ege University Faculty of Medicine Hospital Department of Chest Diseases/Izmir.

出版信息

Sarcoidosis Vasc Diffuse Lung Dis. 2024 Dec 10;41(4):e2024050. doi: 10.36141/svdld.v41i4.15675.

DOI:10.36141/svdld.v41i4.15675

PMID:39655590

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11708949/

Abstract

BACKGROUND AND AIM

Lung cancer is one of the significant comorbidities seen in patients with Idiopathic Pulmonary Fibrosis (IPF). However, there is limited data on non-IPF Pulmonary Fibrosis (PF) patients with lung cancer (LC). The present study aims to compare the characteristics and survival outcomes of patients diagnosed with LC in IPF and non-IPF PF.

METHODS

The multicenter data records of IPF and non-IPF PF patients diagnosed with lung cancer between 2010- 2022 were analyzed in this descriptive, cross-sectional, and retrospective study.

RESULTS

Of the 251 patients involved in this study [164 IPF-LC, 87 non-IPF PF-LC], 89.6% were male, the mean age was 69±7.9 years and the smoking rate was 85.7%. Honeycomb pattern was more frequently observed in IPF-LC patients [62.8%,37.9%p<0.001], whereas ground-glass opacity [33.5%,59.8%p<0.001] and emphysema [37.8%,59.8%p<0.001] were more frequently seen in non-IPF PF-LC patients. The most commonly seen histological type was squamous cell carcinoma [42.7%,33.9%], followed by adenocarcinoma [28.2%; 32.2%]. [46.4%;47.2%] and their 5-year mortality rates were high [64.6%, 63.2%]. The median survival for both groups was 2±0.22 years [median 95% CI (1.55-2.44)]. The shortest survival time was observed in non-IPF PF-LC subgroup with unclassified PF [1±0.253 years median 95% CI (0.50-1.49) (p=0.030)].

CONCLUSIONS

The majority of IPF and non-IPF PF LC patients were male, elderly, and had a high smoking rate. Squamous cell carcinoma was the most frequently seen histological type and they had short survival periods and high mortality rates. The survival period of unclassified non-IPF PF-LC patients was found to be the shortest.

摘要

背景与目的

肺癌是特发性肺纤维化（IPF）患者中常见的严重合并症之一。然而，关于非IPF的肺纤维化（PF）患者合并肺癌（LC）的数据有限。本研究旨在比较IPF和非IPF的PF患者中诊断为LC的患者的特征和生存结果。

方法

在这项描述性、横断面和回顾性研究中，分析了2010年至2022年间诊断为肺癌的IPF和非IPF的PF患者的多中心数据记录。

结果

本研究纳入的251例患者中[164例IPF-LC，87例非IPF PF-LC]，89.6%为男性，平均年龄为69±7.9岁，吸烟率为85.7%。蜂窝状模式在IPF-LC患者中更常见[62.8%，37.9%，p<0.001]，而磨玻璃影[33.5%，59.8%，p<0.001]和肺气肿[37.8%，59.8%，p<0.001]在非IPF PF-LC患者中更常见。最常见的组织学类型是鳞状细胞癌[42.7%，33.9%]，其次是腺癌[28.2%；32.2%]。[46.4%；47.2%]，其5年死亡率较高[64.6%，63.2%]。两组的中位生存期为2±0.22年[中位95%CI（1.55-2.44）]。在未分类PF的非IPF PF-LC亚组中观察到最短的生存时间[1±0.253年，中位95%CI（0.50-1.49）（p=0.030）]。