Aliyeva Kubra, Albayrak Abdulmecit, Toktay Erdem, Yurdgulu Emir Enis, Bayir Yasin
Department of Pharmaceutical Technology and Management, Azerbaijan Medical University Faculty of Pharmacy Baku, Azerbaijan.
Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Türkiye.
Eurasian J Med. 2024 Oct 23;56(3):170-177. doi: 10.5152/eurasianjmed.2024.24550.
Skin injuries, such as burns, can result in an open wound that can lead to the deterioration of the skin, which acts as a protective barrier against external agents, and can cause serious health problems. Pectin, a plant-derived polysaccharide, is a suitable candidate for wound care due to its gel-forming ability and biocompatibility. Pectin absorbs wound exudates to form a soft gel and is known for its strong anti-inflammatory efects. Pectin-based hydrogel systems promote wound healing by promoting fibroblast proliferation and keratinocyte migration. In the study, 60 male Wistar albino rats were used, and 6 diferent treatment groups were formed: Healthy control, burn control, silver sulfadiazine, pectin-based hydrogel system, pectin-based hydrogel system+iodine, pectin-based hydrogel system+plant extract. Rats with burn wounds were treated for 21 days, and the wound healing process was evaluated by macroscopic, biochemical, and histopathological analysis. The results showed that the pectin-based hydrogel system, iodine, and plant extracts promoted healing in burn wounds. Especially in the groups treated with silver sulfadiazine and plant extracts, the development of granulation tissue and regeneration of collagen fibers showed significant improvement. Furthermore, the pectin-based hydrogel system is thought to contribute to wound healing by maintaining skin moisturization. Vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) levels decreased in the treatment groups compared to the burn group, and it was determined that these factors play an important role in wound healing. This study shows that pectin-based hydrogel systems can be an efective alternative in burn treatment, and their healing efects can be enhanced by the addition of iodine and plant extracts.
皮肤损伤，如烧伤，会导致开放性伤口，这可能会使作为抵御外部因素的保护屏障的皮肤恶化，并可能引发严重的健康问题。果胶是一种植物来源的多糖，因其凝胶形成能力和生物相容性，是伤口护理的合适候选材料。果胶吸收伤口渗出液形成软凝胶，并且以其强大的抗炎作用而闻名。基于果胶的水凝胶系统通过促进成纤维细胞增殖和角质形成细胞迁移来促进伤口愈合。在该研究中，使用了60只雄性Wistar白化大鼠，并形成了6个不同的治疗组：健康对照组、烧伤对照组、磺胺嘧啶银、基于果胶的水凝胶系统、基于果胶的水凝胶系统+碘、基于果胶的水凝胶系统+植物提取物。对有烧伤伤口的大鼠进行了21天的治疗，并通过宏观、生化和组织病理学分析评估伤口愈合过程。结果表明，基于果胶的水凝胶系统、碘和植物提取物促进了烧伤伤口的愈合。特别是在使用磺胺嘧啶银和植物提取物治疗的组中，肉芽组织的发育和胶原纤维的再生有显著改善。此外，基于果胶的水凝胶系统被认为通过保持皮肤湿润来促进伤口愈合。与烧伤组相比，治疗组中的血管内皮生长因子（VEGF）和转化生长因子-β（TGF-β）水平降低，并且确定这些因子在伤口愈合中起重要作用。这项研究表明，基于果胶的水凝胶系统在烧伤治疗中可以是一种有效的替代方法，并且通过添加碘和植物提取物可以增强其愈合效果。
