College of Materials Science and Engineering, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab. for Biopolymers and Safety Evaluation, Shenzhen University, Shenzhen, 518055, PR China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, PR China.
Department of Medical Cell Biology & Genetics, Health Science Center, Shenzhen University, Shenzhen, 518055, PR China.
Carbohydr Polym. 2021 Jan 1;251:117005. doi: 10.1016/j.carbpol.2020.117005. Epub 2020 Sep 7.
Hydrogel can provide a favorable moisture environment for skin wound healing. In this study, a novel in-situ crosslinked injectable hydrogel was prepared using the water-soluble amidated pectin (AP) and oxidized chitosan (OC) through Schiff-base reaction without any chemical crosslinker. The influence of AP content on the properties of the hydrogel was systemically investigated. It showed that gelation time, pore structure, swelling capability and degradability of the hydrogel can be tuned by varying the content of amine and aldehyde groups from AP and OC. All the porous hydrogels with various AP contents (65%, 70%, and 80%) presented desirable gelation time, swelling property, high hemocompatibility and biocompatibility. Particularly, AP-OC-65 hydrogel presented superior swelling capability and better hemo- and bio-compatibility, owing to more residual amine sites in the hydrogel. Therefore, the injectable AP-OC-65 hydrogel has a greater potential for application to wound dressing or skin substitute.
水凝胶可为皮肤伤口愈合提供有利的湿润环境。在这项研究中，通过席夫碱反应，使用水溶性酰胺化果胶（AP）和氧化壳聚糖（OC）制备了一种新型的原位交联可注射水凝胶，无需任何化学交联剂。系统研究了 AP 含量对水凝胶性能的影响。结果表明，通过改变 AP 和 OC 中胺基和醛基的含量，可以调节水凝胶的凝胶时间、孔结构、溶胀能力和降解性。所有具有不同 AP 含量（65％、70％和 80％）的多孔水凝胶均具有理想的凝胶时间、溶胀性能、高血液相容性和生物相容性。特别是，AP-OC-65 水凝胶由于水凝胶中存在更多的残留胺基，因此表现出优异的溶胀能力和更好的血液和生物相容性。因此，可注射的 AP-OC-65 水凝胶在伤口敷料或皮肤替代物方面具有更大的应用潜力。
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