Hayashi A, Yoshida Y, Tanaka H, Arima M, Ohno K
J Invest Dermatol. 1985 Jan;84(1):77-8. doi: 10.1111/1523-1747.ep12274850.
It has been reported that some of the cultured cell strains derived from patients with tuberous sclerosis (TS) showed hypersensitivity to gamma-rays or a radiomimetic chemical. Thirteen fibroblast cell strains from 11 patients with TS were examined for their sensitivity to x-rays as determined from their colony-forming ability. All strains derived from normal-appearing skin of patients, either sporadic or familial cases, showed sensitivity within the normal control range. Five cell strains originating from tumorous skin of 3 patients did not show hypersensitivity. It was concluded that the sensitivity to x-rays of cultured cells of TS is essentially normal. However, the mean D0 or D10 values of the strains from tumorous skin tended to be lower compared to those for normal skin of patients. In addition, we could confirm the hypersensitivity to x-rays in the cell strains of TS which had been shown to be hypersensitive to gamma-rays. These results appear to indicate that at least some of the cells of TS are liable to change to exhibit a hypersensitive trait in unknown acquired conditions.
据报道，一些来自结节性硬化症（TS）患者的培养细胞株对γ射线或拟放射性化学物质表现出超敏反应。对11例TS患者的13株成纤维细胞株进行了X射线敏感性检测，通过其集落形成能力来确定。所有来源于散发性或家族性病例患者外观正常皮肤的细胞株，其敏感性均在正常对照范围内。来自3例患者肿瘤性皮肤的5株细胞株未表现出超敏反应。得出的结论是，TS培养细胞对X射线的敏感性基本正常。然而，与患者正常皮肤的细胞株相比，来自肿瘤性皮肤的细胞株的平均D0或D10值往往较低。此外，我们能够证实，那些已被证明对γ射线超敏的TS细胞株对X射线也存在超敏反应。这些结果似乎表明，至少部分TS细胞在未知的获得性条件下易于发生变化，从而表现出超敏特性。
