Ausma Noa S, van der Kraan Yvonne M, de Wolff Liseth, Kokol Helene, Carbo Marlies J G, Kieskamp Stan C, Paap Davy, Spoorenberg Anneke, Bootsma Hendrika, Arends Suzanne
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen (UMCG), University of Groningen, the Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen (UMCG), University of Groningen, the Netherlands; and Department of Medicine, Division of Rheumatology, University of California (UCSF), San Francisco, USA.
Clin Exp Rheumatol. 2024 Dec;42(12):2468-2475. doi: 10.55563/clinexprheumatol/lcbs9m. Epub 2024 Dec 10.
Regular physical activity is recommended in patients with rheumatic diseases. In order to uniformly measure physical activity, our aim was to perform field testing of the modified Short QUestionnaire to ASsess Health enhancing physical activity (mSQUASH) in Sjögren's disease (SjD), together with other rheumatic diseases, and to investigate construct validity and test-retest reliability of the mSQUASH in patients with SjD.
The mSQUASH was tested by conducting semi-structured interviews in patients with SjD (n=10), systemic lupus erythematosus (n=10), giant cell arteritis/polymyalgia rheumatica (n=10) and axial spondyloarthritis (n=13) to check for understandability, interpretation and relevance. For construct validity (n=263 SjD), the association of mSQUASH to other patient-reported outcome measures was analysed using Spearman correlations. It was hypothesised that correlations are highest for physical-related outcomes, with fair to moderate correlations due to partly overlapping constructs. For test-retest reliability (n=75 SjD), intra-class correlation coefficients (ICCs) were calculated and Bland-Altman analysis was performed.
All patient groups perceived the mSQUASH as relevant and easy to complete. Some minor adaptations and clarifications were implemented. As expected, mSQUASH total score showed fair associations with ESSPRI total score (ρ=-0.30) and EQ-5D total score (ρ=-0.34). Within the subdomains, correlations were higher for ESSPRI fatigue and pain compared to dryness and highest for EQ-5D activity and mobility. Test-retest reliability was good, with an ICC of 0.84. Bland-Altman analysis showed no systemic bias, but limits of agreement were wide.
The mSQUASH is a feasible, valid and reliable questionnaire to assess daily physical activity in SjD patients.
建议风湿性疾病患者进行规律的体育活动。为了统一测量体育活动情况，我们的目的是在干燥综合征（SjD）以及其他风湿性疾病中对改良的健康增强型体育活动简短问卷（mSQUASH）进行现场测试，并调查mSQUASH在SjD患者中的结构效度和重测信度。
通过对SjD患者（n = 10）、系统性红斑狼疮患者（n = 10）、巨细胞动脉炎/风湿性多肌痛患者（n = 10）和轴性脊柱关节炎患者（n = 13）进行半结构化访谈来测试mSQUASH，以检查其可理解性、解释性和相关性。对于结构效度（n = 263例SjD患者），使用Spearman相关性分析mSQUASH与其他患者报告的结局指标之间的关联。假设与身体相关的结局指标相关性最高，由于部分结构重叠，相关性为中等。对于重测信度（n = 75例SjD患者），计算组内相关系数（ICC）并进行Bland - Altman分析。
所有患者组都认为mSQUASH相关且易于完成。进行了一些小的调整和说明。正如预期的那样，mSQUASH总分与ESSPRI总分（ρ = -0.30）和EQ - 5D总分（ρ = -0.34）显示出中等关联。在各个子领域中，与干燥相比，ESSPRI疲劳和疼痛的相关性更高；与EQ - 5D活动和 Mobility相比，干燥的相关性最高。重测信度良好，ICC为0.84。Bland - Altman分析显示无系统性偏差，但一致性界限较宽。
mSQUASH是一种可行、有效且可靠的问卷，可用于评估SjD患者的日常体育活动。
