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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases.

作者信息

Fujitani Masashi, Tarif Abu Md Mamun, Otani Yoshinori

机构信息

Department of Anatomy and Neuroscience, Faculty of Medicine, Shimane University, Shimane, Japan.

出版信息

Neural Regen Res. 2025 Jan 1;20(1):193-194. doi: 10.4103/NRR.NRR-D-23-02055. Epub 2024 Apr 3.

DOI:10.4103/NRR.NRR-D-23-02055
PMID:39657086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11246139/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4c0/11246139/c315247ba506/NRR-20-193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4c0/11246139/c315247ba506/NRR-20-193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4c0/11246139/c315247ba506/NRR-20-193-g001.jpg

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2
Blocking insulin-like growth factor 1 receptor signaling pathway inhibits neuromuscular junction regeneration after botulinum toxin-A treatment.阻断胰岛素样生长因子 1 受体信号通路抑制肉毒毒素 A 治疗后神经肌肉接头的再生。
Cell Death Dis. 2023 Sep 16;14(9):609. doi: 10.1038/s41419-023-06128-w.
3
Skeletal muscle in amyotrophic lateral sclerosis.肌萎缩侧索硬化症的骨骼肌。
Brain. 2023 Nov 2;146(11):4425-4436. doi: 10.1093/brain/awad202.
4
Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.肌萎缩侧索硬化症：一种神经退行性疾病，有望成功实现治疗转化。
Nat Rev Drug Discov. 2023 Mar;22(3):185-212. doi: 10.1038/s41573-022-00612-2. Epub 2022 Dec 21.
5
Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis.肌萎缩侧索硬化症中的神经肌肉接头功能障碍。
Mol Neurobiol. 2022 Mar;59(3):1502-1527. doi: 10.1007/s12035-021-02658-6. Epub 2022 Jan 8.
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A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved.从神经肌肉角度探讨少肌症发病机制：解析相关信号通路。
Geroscience. 2022 Jun;44(3):1199-1213. doi: 10.1007/s11357-021-00510-2. Epub 2022 Jan 4.
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The Neuromuscular Junction: Roles in Aging and Neuromuscular Disease.神经肌肉接头：在衰老和神经肌肉疾病中的作用。
Int J Mol Sci. 2021 Jul 28;22(15):8058. doi: 10.3390/ijms22158058.
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Small junction, big problems: Neuromuscular junction pathology in mouse models of amyotrophic lateral sclerosis (ALS).小接头，大问题：肌萎缩侧索硬化症 (ALS) 小鼠模型中的神经肌肉接头病理学。
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The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis.健康与疾病中的神经肌肉接头：调控突触形成和稳态的分子机制
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