Hashimoto Takehiro, Uchida Hiroki, Shibata Hirotaka, Hiramatsu Kazufumi
Hospital Infection Control Center, Oita University Hospital, Oita, Japan.
Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Oita University Faculty of Medicine, Oita, Japan.
Am J Trop Med Hyg. 2024 Dec 10;112(3):525-527. doi: 10.4269/ajtmh.24-0572. Print 2025 Mar 5.
Methylobacterium populi is a fastidious, pink-pigmented, Gram-negative bacterium that has been isolated from poplar trees that are found throughout the Northern Hemisphere in both temperate and subtropical regions. Herein, we report a novel case of M. populi peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD). A 45-year-old Japanese man with a history of hypertension and chronic kidney disease was diagnosed with CAPD-associated peritonitis. After starting broad-spectrum antibiotics, white blood cell (WBC) count in the CAPD effluent remained elevated. On day 7, the CAPD effluent grew Gram-negative vacuolated rods identified as M. populi using 16S ribosomal RNA gene sequences. After the treatment regimen was changed to intraperitoneal gentamicin, the WBC count in the CAPD effluent decreased, and the clinical features improved. Although infection with M. populi is rare, clinicians should advise patients on CAPD to avoid contact with poplar trees and provide training on adherence to CAPD exchange protocols, including hand hygiene.
杨树甲基杆菌是一种苛求、粉红色素沉着、革兰氏阴性菌，已从在北半球温带和亚热带地区均有发现的杨树中分离出来。在此，我们报告一例与持续性非卧床腹膜透析（CAPD）相关的杨树甲基杆菌腹膜炎新病例。一名有高血压和慢性肾脏病病史的45岁日本男性被诊断为CAPD相关性腹膜炎。开始使用广谱抗生素后，CAPD流出液中的白细胞（WBC）计数仍居高不下。在第7天，CAPD流出液培养出革兰氏阴性空泡状杆菌，通过16S核糖体RNA基因序列鉴定为杨树甲基杆菌。在治疗方案改为腹腔内注射庆大霉素后，CAPD流出液中的WBC计数下降，临床症状改善。尽管杨树甲基杆菌感染罕见，但临床医生应建议进行CAPD的患者避免接触杨树，并提供关于遵守CAPD交换方案（包括手部卫生）的培训。
