Arshadi Maedeh, Ghazal Nima, Ghavidel Fatemeh, Beygi Zahra, Nasiri Zohal, Zarepour Pardis, Abdollahi Sedigheh, Azizi Hosein, Khodamoradi Farzad
Department of Epidemiology and Biostatistics, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Student Research Committee of Shahid Sadougi University of Medical Sciences, Yazd Iran.
Clin Nutr ESPEN. 2025 Feb;65:400-407. doi: 10.1016/j.clnesp.2024.12.001. Epub 2024 Dec 8.
For a comprehensive evaluation and due to the inconsistent results of previous studies, we performed this meta-analysis with the aim of vitamin C effect on breast cancer and prostate cancer and colorectal cancer.
PubMed, Scopus and Web of Science were searched to identify studies on the association between vitamin C and breast cancer, prostate cancer and colorectal cancer through September 11, 2023. The pooled RR and the 95 % confidence intervals were used to measure the association between vitamin C and breast cancer, prostate cancer and colorectal cancer by assuming a random effects meta-analytic model. Newcastle-Ottawa scale was used for quality appraisal.
A total of 69 studies were included. The pooled RR for the association between vitamin C (dietary) and breast cancer in the cohort study was 0.99 [95 % CI: 0.95, 1.03], but the pooled RR in the case-control study was 0.72 [95 % CI: 0.60, 0.85]. No association was found between vitamin E (supplemental, total intake) and breast cancer in studies. The pooled RR for the association between vitamin C (dietary) and prostate cancer was 0.88 [95 % CI: 0.77, 1.00], which represents a decrease in prostate cancer. No association was found between vitamin C (supplemental) and prostate cancer in studies. The pooled RR for the association between vitamin C (dietary) and colorectal cancer was 0.55 [95 % CI: 0.42, 0.73], which represents a decrease in colorectal cancer.
Our analysis shows an inverse significant relationship between vitamin C (dietary) and breast cancer in the case-control study. Also between vitamin C (dietary) and prostate cancer and colorectal cancer in studies, which represents a decrease in cancers.
为了进行全面评估，且由于先前研究结果不一致，我们开展了这项荟萃分析，旨在探讨维生素C对乳腺癌、前列腺癌和结直肠癌的影响。
检索了PubMed、Scopus和Web of Science数据库，以确定截至2023年9月11日关于维生素C与乳腺癌、前列腺癌和结直肠癌之间关联的研究。采用随机效应荟萃分析模型，用合并相对危险度（RR）和95%置信区间来衡量维生素C与乳腺癌、前列腺癌和结直肠癌之间的关联。使用纽卡斯尔-渥太华量表进行质量评估。
共纳入69项研究。队列研究中，维生素C（饮食摄入）与乳腺癌之间关联的合并RR为0.99 [95%置信区间：0.95，1.03]，但病例对照研究中的合并RR为0.72 [95%置信区间：0.60，0.85]。研究中未发现维生素E（补充剂、总摄入量）与乳腺癌之间存在关联。维生素C（饮食摄入）与前列腺癌之间关联的合并RR为0.88 [95%置信区间：0.77，1.00]，这表明前列腺癌有所减少。研究中未发现维生素C（补充剂）与前列腺癌之间存在关联。维生素C（饮食摄入）与结直肠癌之间关联的合并RR为0.55 [95%置信区间：0.42，0.73]，这表明结直肠癌有所减少。
我们的分析表明，在病例对照研究中，维生素C（饮食摄入）与乳腺癌之间存在显著负相关。在研究中，维生素C（饮食摄入）与前列腺癌和结直肠癌之间也存在显著负相关，这表明癌症发病率有所降低。
