Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-01, Singapore 117549, Singapore.
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Republic of Korea.
Nutrients. 2022 Dec 21;15(1):14. doi: 10.3390/nu15010014.
Vitamin E is a group of antioxidative tocopherols and tocotrienols that play a potential role in chemoprevention. Studies investigating the association between vitamin E and prostate cancer risk have been conflicting. We identified observational and interventional studies examining the association between vitamin E intake and prostate cancer risk from PubMed, EMBASE and the Cochrane Library. A random-effects model was used to perform a meta-analysis and estimate relative risks (RRs) and the corresponding 95% confidence intervals (CIs) of prostate cancer risk according to vitamin E intake. Subgroup analyses were conducted by study design, sample size, study population characteristics, geographical region, and dose of vitamin E intake. The association between dietary (RR = 0.97; 95% CI = 0.92-1.02) and supplemental (RR = 0.99; 95% CI = 0.94-1.04) vitamin E intake on prostate cancer risk was non-significant. In subgroup analyses, supplemental vitamin E was significantly associated with reduced prostate cancer risk in studies in Europe (RR = 0.81, 95% CI = 0.69-0.97). Overall, this meta-analysis demonstrates little evidence for a beneficial effect of vitamin E intake on prostate cancer risk but suggests that there may be some conditions in which supplements could confer a protective effect on prostate cancer risk.
维生素 E 是一组具有抗氧化作用的生育酚和三烯生育酚，它们在化学预防中发挥潜在作用。研究维生素 E 与前列腺癌风险之间的关系的研究结果存在矛盾。我们从 PubMed、EMBASE 和 Cochrane 图书馆中确定了观察性和干预性研究，这些研究调查了维生素 E 摄入与前列腺癌风险之间的关联。使用随机效应模型进行荟萃分析，并根据维生素 E 摄入情况估计前列腺癌风险的相对风险 (RR) 和相应的 95%置信区间 (CI)。根据研究设计、样本量、研究人群特征、地理位置和维生素 E 摄入剂量进行亚组分析。饮食 (RR = 0.97；95% CI = 0.92-1.02) 和补充 (RR = 0.99；95% CI = 0.94-1.04) 维生素 E 摄入与前列腺癌风险之间的关联无统计学意义。在亚组分析中，在欧洲的研究中，补充维生素 E 与前列腺癌风险降低显著相关 (RR = 0.81，95% CI = 0.69-0.97)。总体而言，这项荟萃分析几乎没有证据表明维生素 E 摄入对前列腺癌风险有有益影响，但表明在某些情况下，补充剂可能对前列腺癌风险具有保护作用。
