Blanc P, Hogan M, Mallin K, Hryhorczuk D, Hessl S, Bernard B
JAMA. 1985 Jan 18;253(3):367-71.
Thirty-six former workers in a silver-reclaiming facility who had been exposed over a long-term to excessive levels of cyanide were studied to determine acute and residual toxic reactions. The study involved physical examinations, laboratory studies, and a questionnaire to determine levels of exposure, symptoms during employment, and current symptoms. Questionnaire data showed that during the time of active employment there was a high prevalence of symptoms that are consistent with acute cyanide toxic reactions. A significant positive trend for prevalence of cyanide-related symptoms measured against levels of exposure was demonstrated, supporting a dose-response effect. Some symptoms occurring seven or more months after exposure had ceased also exhibited a dose-response trend. Mild abnormalities of vitamin B12, folate, and thyroid function were detected and suggest long-term cyanide effects.
对36名曾在一家银回收工厂长期接触过量氰化物的前工人进行了研究，以确定急性和残留毒性反应。该研究包括体格检查、实验室检查以及一份问卷，以确定接触水平、工作期间的症状和当前症状。问卷数据显示，在实际工作期间，与急性氰化物毒性反应相符的症状普遍存在。针对接触水平测量的氰化物相关症状患病率呈现出显著的正趋势，支持剂量反应效应。接触停止七个或更多月后出现的一些症状也呈现出剂量反应趋势。检测到维生素B12、叶酸和甲状腺功能存在轻度异常，提示存在长期氰化物影响。
