慢性氰化物暴露：一项临床、放射性同位素及实验室研究。
Chronic cyanide exposure: a clinical, radioisotope, and laboratory study.
作者信息
El Ghawabi S H, Gaafar M A, El-Saharti A A, Ahmed S H, Malash K K, Fares R
出版信息
Br J Ind Med. 1975 Aug;32(3):215-9. doi: 10.1136/oem.32.3.215.
The effect of chronic cyanide exposure in the electroplating sections of three factories employing 36 workers was studied and compared with a control group. The concentration of cyanides to which the workers were exposed was measured. The regression line showing the relationship between thiocyanates in urine and the concentration of cyanides in the air was plotted. Increased percentages of haemoglobin and lymphocyte count were present in all exposed workers, in addition to punctate basophilia in 28 workers. Cyanmethaemoglobin was found to be characteristic. Apart from other complaints, two men with psychosis similar to one case reported in therapeutic thiocyanate intoxication were found. Twenty of the workers had thyroid enlargements to a variable degree and consistency, in two of whom it resembled lymphadenoid goitre. Thyroid 131I uptakes at 4 and 24 hours were significantly higher than in the controls, while 131PBI was unchanged. The reason for this iodine deficiency-like action is discussed.
对三家工厂电镀车间36名工人长期接触氰化物的影响进行了研究，并与一个对照组进行了比较。测定了工人接触的氰化物浓度。绘制了显示尿中硫氰酸盐与空气中氰化物浓度之间关系的回归线。所有接触氰化物的工人血红蛋白和淋巴细胞计数百分比均升高，此外，28名工人出现点彩嗜碱性粒细胞增多。发现氰化高铁血红蛋白具有特征性。除了其他不适外，还发现两名患有精神病的男子，其症状与治疗性硫氰酸盐中毒报告的一例相似。20名工人甲状腺有不同程度的肿大，质地不一，其中两名类似淋巴腺样甲状腺肿。甲状腺4小时和24小时的131I摄取量显著高于对照组，而131PBI不变。文中讨论了这种类似碘缺乏作用的原因。
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