de Mesquita Raíssa Araújo, Takeuchi Elma Vieira, Cardoso de Oliveira Pereira Maria Eduarda, Araújo Jesuina Lamartine Nogueira, Alves Eliane Bermeguy, Silva Cecy Martins
Department of Restorative Dentistry, School of Dentistry, Federal University of Pará, Belém, PA, Brazil.
Eur J Dent. 2025 May;19(2):323-329. doi: 10.1055/s-0044-1789603. Epub 2024 Dec 10.
This randomized, controlled, single-blind, split-mouth clinical study evaluated the effect of the application of a glutaraldehyde-based desensitizer on the prevention of tooth sensitivity (TS) and the changes in the color of the teeth after bleaching.
Twenty-five patients were selected for participation in the study according to the inclusion and exclusion criteria. The patients' right and left hemiarches were randomized into two groups: the placebo group, which received distilled water application and whitening treatment, and the Gluma group, which received Gluma application, followed by whitening treatment. The patients were examined after three bleaching sessions with 35% hydrogen peroxide. TS was measured using a numerical rating scale for 21 days from the beginning of bleaching. The tooth color was monitored using a spectrophotometer at times T0 (baseline) and T1 (after 21 days). The color analysis results were recorded using the CieLab system; the CIEDE2000 formula was applied to obtain the ΔE and ΔL values.
For statistical analysis, the Friedman analysis of variance test was used for intragroup evaluation, and the Wilcoxon test was used for a between-group comparison of the TS results. Student's -test paired the ΔE and ΔL values of the groups. A 5% significance level was adopted.
Intragroup analysis of the sensitivity results showed a statistically significant difference between the pain levels evaluated through days 1 to 21 ( < 0.001), and the highest median values were observed on the days when the whitening sessions were performed (days 1, 8, and 15) and right after the sessions (days 2, 9, and 16). However, in the intergroup analysis, no statistical difference in sensitivity was found between the placebo and Gluma. No statistical difference was found between the influences of the placebo and Gluma treatments on the color obtained after tooth whitening using parameters ᐃE and ᐃL ( > 0.05).
The use of Gluma prior to bleaching does not prevent TS and does not interfere with the color results obtained by tooth bleaching.
本随机、对照、单盲、双侧对照临床研究评估了一种基于戊二醛的脱敏剂在预防牙齿敏感（TS）以及漂白后牙齿颜色变化方面的效果。
根据纳入和排除标准，选择25名患者参与本研究。将患者的左右半口随机分为两组：安慰剂组，接受蒸馏水涂抹和美白治疗；Gluma组，接受Gluma涂抹，随后进行美白治疗。使用35%过氧化氢进行三次漂白疗程后对患者进行检查。从漂白开始起21天内，使用数字评分量表测量牙齿敏感情况。在T0（基线）和T1（21天后）使用分光光度计监测牙齿颜色。使用CieLab系统记录颜色分析结果；应用CIEDE2000公式获得ΔE和ΔL值。
统计分析中，采用Friedman方差分析检验进行组内评估，采用Wilcoxon检验对牙齿敏感结果进行组间比较。采用学生t检验对两组的ΔE和ΔL值进行配对。采用5%的显著性水平。
组内敏感性结果分析显示，第1至21天评估的疼痛水平之间存在统计学显著差异（P<0.001），在进行美白疗程当天（第1、8和15天）以及疗程刚结束后（第2、9和16天）观察到最高中位数。然而，在组间分析中，安慰剂组和Gluma组之间在敏感性方面未发现统计学差异。使用参数ΔE和ΔL，安慰剂组和Gluma组治疗对牙齿美白后获得的颜色影响之间未发现统计学差异（P>0.05）。
漂白前使用Gluma不能预防牙齿敏感，也不影响牙齿漂白后的颜色结果。
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