Watson R G, van Hoorn Hickman R, Terblanche J
J Surg Res. 1985 Jan;38(1):7-12. doi: 10.1016/0022-4804(85)90003-4.
Bile duct ligation (BDL) in the pig results uniformly in fatal oesophago-gastric ulceration which appears to be related to hypersecretion of acid. The presence of bile in normal porcine gastric juice may interfere with studies of acid secretion. The present studies were conducted in pigs with the stomach divided into two separate pouches (proximal and antral) which allowed individual collection of acid or alkali secretion. In normal pigs, division of the stomach resulted in a 30-50% decrease in secretion, rather than any increase in measureable acid. In BDL pigs, there was an 8- to 15-fold increase in alkali collection by antral pouches which may have been in response to acid hypersecretion, or merely duodenal or pancreatic juice reflux. No normal pigs with divided stomachs developed significant ulceration suggesting that such ulcers were not related to exclusion of bile from the stomach. It is proposed that a total gastric fistula may be used in the pig for studies of acid secretion, and that the model with divided stomach may be used for assessment of the effects of secretagogues or hormones upon individual acid or alkali secretion.
猪胆管结扎（BDL）会一致导致致命的食管 - 胃溃疡，这似乎与胃酸分泌过多有关。正常猪胃液中胆汁的存在可能会干扰胃酸分泌的研究。本研究在胃被分成两个独立囊袋（近端和胃窦）的猪身上进行，这样可以分别收集酸或碱的分泌液。在正常猪中，胃的分隔导致分泌减少30 - 50%，而不是可测量的胃酸增加。在胆管结扎猪中，胃窦囊袋收集的碱增加了8至15倍，这可能是对胃酸分泌过多的反应，或者仅仅是十二指肠或胰液反流。没有胃被分隔的正常猪出现明显溃疡，这表明此类溃疡与胆汁被排除在胃外无关。有人提出，在猪身上可以使用全胃瘘来研究胃酸分泌，并且胃被分隔的模型可用于评估促分泌剂或激素对个体酸或碱分泌的影响。
