Arnot R S, Terblanche J, van Hoorn Hickman R, Barbezat G O, Louw J H
S Afr Med J. 1979 Oct 6;56(15):606-8.
Bile duct ligation is associated with severe gastric ulceration in the pig, but the pathogenesis is unknown. Gastric acid secretion was therefore studied before and after bile duct ligation in pigs with Heidenhain pouches. Basal pouch secretion and the response to submaximal pentagastrin stimulation incresed significantly 6--14 days after ligation of the common bile duct (P < 0,05). Bile duct ligation was not followed by gastric ulceration in the pigs in this study which had had, in effect, a 50--70% gastric resection in the course of fashioning the Heidenhain pouch. These observations suggest that oesophagogastric junction ulceration in pigs is associated with gastric acid hypersecretion.
胆管结扎与猪的严重胃溃疡有关，但发病机制尚不清楚。因此，对具有海登海因小胃的猪在胆管结扎前后的胃酸分泌进行了研究。胆总管结扎后6 - 14天，基础小胃分泌以及对次最大剂量五肽胃泌素刺激的反应显著增加（P < 0.05）。在本研究中，在制作海登海因小胃的过程中实际上进行了50 - 70%胃切除的猪，胆管结扎后并未出现胃溃疡。这些观察结果表明，猪的食管胃交界处溃疡与胃酸分泌过多有关。
