Vogel Laura, Güttler Markus, Theinert Kirsten B, Snedec Teja, Reichelt Kristin, Pietsch Fabian, Schären-Bannert Melanie, Rachidi Fanny, Dobeleit Gabriele, Fuhrmann Herbert, Spilke Joachim, Edlich Frank, Starke Alexander
Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
Institute of Biochemistry, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
Front Cell Dev Biol. 2024 Nov 26;12:1370717. doi: 10.3389/fcell.2024.1370717. eCollection 2024.
Current lifestyles are leading to a worldwide increase in metabolic liver diseases that favor the development of liver disease. Changes in hepatocytes are caused by altered lipid concentrations, oxidative stress or toxicity by individual lipids. The complexity of the underlying processes and differences of the pathology to proposed rodent models makes the development of an effective targeted therapy difficult. The lipid mobilization that occurs in dairy cows in the period could be a natural model for the metabolic stress commonly observed in the development of liver diseases. We therefore used gas chromatography and histopathological staining techniques to analyze lipid patterns in diparous and multiparous cows during the peripartum period. The most striking change in lipid composition is the homogenous increase in palmitoleic acid (C16:1n7) content in all cows around the time of calving, with multiparous cows exhibiting consistently higher C16:1n7 levels by the end of the study. Elevated C16:1n7 levels have a potential key role in the development of non-alcoholic steatohepatitis (NASH) and tumorigenesis in the liver. Changes in C16:1n7, therefore, support the idea that lipid mobilization in dairy cows could serve as model for various liver diseases, such as nonalcoholic fatty liver disease (NAFLD) or NASH development.
当前的生活方式正导致全球代谢性肝病发病率上升，这类疾病会促使肝脏疾病的发展。肝细胞的变化是由脂质浓度改变、氧化应激或个别脂质的毒性引起的。潜在过程的复杂性以及与所提出的啮齿动物模型在病理学上的差异，使得开发有效的靶向治疗方法变得困难。奶牛在围产期发生的脂质动员可能是肝病发展过程中常见的代谢应激的天然模型。因此，我们使用气相色谱法和组织病理学染色技术来分析经产和初产奶牛在围产期的脂质模式。脂质组成最显著的变化是在产犊前后所有奶牛中棕榈油酸（C16:1n7）含量均呈现均匀增加，到研究结束时经产奶牛的C16:1n7水平一直较高。C16:1n7水平升高在非酒精性脂肪性肝炎（NASH）的发展和肝脏肿瘤发生中具有潜在关键作用。因此，C16:1n7的变化支持了奶牛脂质动员可作为各种肝病（如非酒精性脂肪性肝病（NAFLD）或NASH发展）模型的观点。
