Curtis Kaya L, Stubblefield Onajia, Lipner Shari R
Weill Cornell Medical College, New York, NY, USA.
University of Louisville School of Medicine, Louisville, KY, USA.
Skin Appendage Disord. 2024 Dec;10(6):520-523. doi: 10.1159/000539424. Epub 2024 Jun 26.
Previous studies have demonstrated association of alopecia areata (AA) with anxiety and depression. However, few case-control studies have evaluated AA association with posttraumatic stress disorder and lifestyle factors, including alcohol use. We aimed to assess associations of AA with psychiatric disorders and lifestyle factors using a national database.
A nested case-control study using the National Institutes of Health database was conducted analyzing patients ≥18 years with AA diagnosis and controls matched 1:4 by age, sex at birth, and self-reported ethnicity/race.
There were 957 AA patients and 3,828 controls included in the final analysis. AA patients versus controls had higher odds of depression, posttraumatic stress disorder, anxiety, and alcohol use. AA patients had decreased odds of smoking.
Our study demonstrates previously understudied AA associations with posttraumatic stress disorder, obesity, and alcohol use, and corroborates high burden of anxiety and depression among AA patients. We recommend screening AA patients for psychiatric disorders and alcohol use and appropriate referrals to psychiatry.
既往研究已证实斑秃（AA）与焦虑和抑郁有关联。然而，很少有病例对照研究评估AA与创伤后应激障碍及包括饮酒在内的生活方式因素之间的关联。我们旨在利用一个全国性数据库评估AA与精神障碍及生活方式因素之间的关联。
采用美国国立卫生研究院数据库进行一项巢式病例对照研究，分析年龄≥18岁的AA诊断患者以及按年龄、出生时性别和自我报告的种族/民族以1:4匹配的对照。
最终分析纳入了957例AA患者和3828例对照。与对照相比，AA患者患抑郁症、创伤后应激障碍、焦虑症及饮酒的几率更高。AA患者吸烟几率降低。
我们的研究表明，AA与创伤后应激障碍、肥胖和饮酒之间存在此前未充分研究的关联，并证实了AA患者中焦虑和抑郁的高负担。我们建议对AA患者进行精神障碍和饮酒筛查，并酌情转诊至精神科。
