Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu City 807-8555, Japan.
Int J Mol Sci. 2022 Jan 18;23(3):1038. doi: 10.3390/ijms23031038.
Alopecia areata is a representative inflammatory skin disease that is associated with various environmental stimuli. While psychological stress is believed to be a major pathogenetic trigger in alopecia areata, infants and newborns also suffer from the disease, suggesting the possible presence of other environmental factors. Daily lifestyle is well known to be involved in various inflammatory diseases and influences the severity of inflammatory skin diseases. However, only a limited number of studies have summarized these influences on alopecia areata. In this review article, we summarize lifestyle factor-related influences on the pathogenesis of alopecia areata and focus on environmental factors, such as smoking, alcohol consumption, sleep, obesity, fatty acids, and gluten consumption.
斑秃是一种具有代表性的炎症性皮肤病,与各种环境刺激有关。虽然心理压力被认为是斑秃的主要发病诱因,但婴儿和新生儿也患有这种疾病,这表明可能存在其他环境因素。众所周知,日常生活方式与各种炎症性疾病有关,并影响炎症性皮肤病的严重程度。然而,只有少数研究总结了这些对斑秃的影响。在这篇综述文章中,我们总结了生活方式因素对斑秃发病机制的影响,并重点关注了环境因素,如吸烟、饮酒、睡眠、肥胖、脂肪酸和麸质摄入。