Qiao Yun, Wang Mei, Hui Kaiyuan, Jiang Xiaodong
Department of Oncology, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China.
Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China.
Front Oncol. 2024 Nov 26;14:1510443. doi: 10.3389/fonc.2024.1510443. eCollection 2024.
Carcinoma of unknown primary (CUP) is a common and complex type of tumor in clinical practice, where the primary site cannot be determined through conventional diagnostic methods, posing significant challenges for clinical diagnosis and treatment. In recent years, advancements in gene expression profiling and genetic testing technologies have provided new perspectives for CUP research, driving progress in this field. By analyzing gene expression profiles, researchers can more effectively identify the tissue origin of tumors, thereby improving diagnostic accuracy. At the same time, the potential application of genetic testing is continuously being explored, offering new possibilities for personalized treatment. This article aims to discuss the latest advancements in the diagnosis of CUP, analyze the importance of gene expression profiling and genetic testing in tumor origin identification and their clinical applications, and summarize current research progress and future research directions, with the goal of providing a theoretical basis for the early diagnosis and treatment of CUP.
原发灶不明癌（CUP）是临床实践中一种常见且复杂的肿瘤类型，通过传统诊断方法无法确定其原发部位，给临床诊断和治疗带来了重大挑战。近年来，基因表达谱分析和基因检测技术的进步为CUP研究提供了新视角，推动了该领域的进展。通过分析基因表达谱，研究人员能够更有效地识别肿瘤的组织起源，从而提高诊断准确性。同时，基因检测的潜在应用也在不断探索，为个性化治疗提供了新的可能性。本文旨在探讨CUP诊断的最新进展，分析基因表达谱分析和基因检测在肿瘤起源识别中的重要性及其临床应用，并总结当前的研究进展和未来的研究方向，以期为CUP的早期诊断和治疗提供理论依据。
