Jeskey Jack, Kurien Christine, Blunk Henry, Sehmi Kiran, Areti Sathya, Nguyen Delena, Hostoffer Robert
Department of Pulmonary & Critical Care, Allergy and Immunology Division, Case Western Reserve University/University Hospitals Cleveland Medical Center Program, Cleveland, OH.
J Pediatr Pharmacol Ther. 2024 Dec;29(6):587-603. doi: 10.5863/1551-6776-29.6.587. Epub 2024 Dec 9.
Atopic dermatitis, more commonly known as atopic eczema, is a chronic, relapsing inflammatory skin disorder characterized by dry skin, localized erythematous rash, and intense pruritus. The clinical manifestations are variable and age dependent. As one of the most common skin disorders globally, atopic dermatitis poses a significant clinical and economic burden on affected patients. Individual treatment strategies are imperative in improving patient outcomes and reducing these burdens. Recent advances in understanding the genetic, immunologic, and environmental factors influencing atopic dermatitis have opened avenues for novel treatment modalities. This article highlights the clinical presentation, pathophysiology, diagnosis criteria, as well as current recommendations on treatment of atopic dermatitis.
特应性皮炎，更常见的名称是特应性湿疹，是一种慢性复发性炎症性皮肤病，其特征为皮肤干燥、局限性红斑疹和剧烈瘙痒。临床表现多样且与年龄有关。作为全球最常见的皮肤疾病之一，特应性皮炎给受影响的患者带来了重大的临床和经济负担。个体化治疗策略对于改善患者预后和减轻这些负担至关重要。在理解影响特应性皮炎的遗传、免疫和环境因素方面的最新进展为新型治疗方式开辟了道路。本文重点介绍特应性皮炎的临床表现、病理生理学、诊断标准以及当前的治疗建议。
