Zhang Huaming, Zhang Min, Hao Lina, Li Qianqian, Li Qijian, Yang Jia, Xie Yanhu
Department of Anaesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People's Republic of China.
Drug Des Devel Ther. 2024 Dec 5;18:5701-5707. doi: 10.2147/DDDT.S489223. eCollection 2024.
To evaluate and compare the effects of ciprofol and propofol on postoperative nausea and vomiting (PONV) in patients undergoing outpatient hysteroscopy.
Double-blind randomized controlled trial.
This study included 1104 patients scheduled for elective outpatient hysteroscopy. Patients were randomly grouped to ciprofol Group (Group C, n = 539) and propofol Group (Group P, n = 547). Anesthesia was induced by sufentanil 0.1 ug/kg combined with ciprofol 0.3mg/kg or propofol 2.5mg/kg. Anesthesia was maintained by ciprofol 1 to 1.5mg/kg/h or propofol 3 to 5mg/kg/h. The primary outcome of the study was PONV after surgery 1h and 24h. Secondary outcomes included heart rate (HR), mean arterial blood pressure (MAP), SpO before anesthesia (T1), 3 min after anesthesia (T2) and at the end of surgery (T3); the time of consciousness loss, recovery, hysteroscopy and discharge; and the incidence of adverse drug reactions such as hypotension, respiratory depression, bradycardia and injection pain was recorded in the two groups.
Compared with group P, MAP and SpO2 at T2 were significantly increased in group C (<0.05). Although there was no significant difference in the incidence of PONV at 1h and 24h after surgery between 2 groups ( > 0.05), the incidence of hypotension, injection pain and respiratory depression in group C were significantly reduced, compared with group P. (<0.05).
Compared with propofol, ciprofol has a similar incidence of PONV and lower adverse effects such as hypotension, injection pain and respiratory depression in outpatient hysteroscopy.
评估并比较环泊酚与丙泊酚对门诊宫腔镜手术患者术后恶心呕吐（PONV）的影响。
双盲随机对照试验。
本研究纳入1104例计划行择期门诊宫腔镜手术的患者。患者被随机分为环泊酚组（C组，n = 539）和丙泊酚组（P组，n = 547）。麻醉诱导采用舒芬太尼0.1μg/kg联合环泊酚0.3mg/kg或丙泊酚2.5mg/kg。麻醉维持采用环泊酚1至1.5mg/kg/h或丙泊酚3至5mg/kg/h。本研究的主要结局是术后1小时和24小时的PONV。次要结局包括心率（HR）、平均动脉压（MAP）、麻醉前（T1）、麻醉后3分钟（T2）及手术结束时（T3）的血氧饱和度（SpO₂）；意识消失、恢复、宫腔镜手术及出院时间；记录两组低血压、呼吸抑制、心动过缓和注射痛等药物不良反应的发生率。
与P组相比，C组T2时的MAP和SpO₂显著升高（<0.05）。虽然两组术后1小时和24小时PONV的发生率无显著差异（>0.05），但与P组相比，C组低血压、注射痛和呼吸抑制的发生率显著降低（<0.05）。
在门诊宫腔镜手术中，与丙泊酚相比，环泊酚的PONV发生率相似，且低血压、注射痛和呼吸抑制等不良反应更低。
