Zhao Li, Zhou Xuelei, Zhang Ting, Mao Wei, Chen Linlin, Guo Yiping, Liu Xianchun, Zhang Longyi, Li Linji
Department of Anesthesiology, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong Central Hospital, Nanchong, China.
Nanchong Center for Disease Control and Prevention, Nanchong, China.
Sci Rep. 2025 Apr 7;15(1):11864. doi: 10.1038/s41598-025-95135-2.
To determine the median effective dose (ED50) and the 95% effective dose (ED95) of ciprofol combined with sufentanil for inhibiting the tracheal intubation response in female patients and to evaluate the hemodynamic stability and adverse events associated with this drug combination. This was a prospective dose-finding study using an up-and-down sequential allocation method. A total of 30 female patients undergoing general anesthesia surgeries between November 2024 and December 2024 were enrolled. Patients were administered ciprofol for induction, with an initial dose of 0.4 mg/kg and subsequent doses adjusted based on the presence or absence of an intubation response. The primary outcome was the ED50 of ciprofol, with secondary outcomes including patient baseline characteristics, hemodynamic parameters, and adverse events. The ED50 and ED95 of ciprofol for inhibiting tracheal intubation response were 0.318 mg/kg and 0.496 mg/kg, respectively. Patients with a positive tracheal intubation response had significantly higher heart rates and mean arterial pressures, as well as a higher incidence of hypertension and body movement. The ED50 and ED95 of ciprofol combined with sufentanil for suppressing the response to tracheal intubation in female patients were 0.318 mg/kg and 0.496 mg/kg, respectively.
确定丙泊酚联合舒芬太尼抑制女性患者气管插管反应的半数有效剂量（ED50）和95%有效剂量（ED95），并评估该药物组合相关的血流动力学稳定性和不良事件。这是一项采用序贯上下分配法的前瞻性剂量探索研究。纳入了2024年11月至2024年12月期间接受全身麻醉手术的30例女性患者。患者诱导时给予丙泊酚，初始剂量为0.4mg/kg，随后根据有无插管反应调整剂量。主要结局是丙泊酚的ED50，次要结局包括患者基线特征、血流动力学参数和不良事件。丙泊酚抑制气管插管反应的ED50和ED95分别为0.318mg/kg和0.496mg/kg。气管插管反应阳性的患者心率和平均动脉压显著更高，高血压和身体移动的发生率也更高。丙泊酚联合舒芬太尼抑制女性患者气管插管反应的ED50和ED95分别为0.318mg/kg和0.496mg/kg。
