O'Dougherty M, Wright F S, Loewenson R B, Torres F
Neurology. 1985 Jan;35(1):42-6. doi: 10.1212/wnl.35.1.42.
Although the long-term effects of acute anoxia have been studied, the effects of chronic hypoxia on the developing human brain have received little attention. We studied children with a cyanotic congenital heart defect to assess the impact of chronic hypoxia by eight measures: neurologic examination, visual evoked response, EEG, behavioral adjustment, cognitive, perceptual-motor, and attentional functioning, and school performance. On outcome evaluation, these children evidenced diverse neurophysiologic dysfunction. Chronic hypoxia was associated with impaired motor function, inability to sustain attention, and low academic achievement.
尽管已经对急性缺氧的长期影响进行了研究，但慢性缺氧对发育中的人类大脑的影响却很少受到关注。我们研究了患有青紫型先天性心脏病的儿童，通过八项指标评估慢性缺氧的影响：神经学检查、视觉诱发电位、脑电图、行为调整、认知、感知运动和注意力功能以及学业成绩。在结果评估中，这些儿童表现出多种神经生理功能障碍。慢性缺氧与运动功能受损、无法持续集中注意力以及学业成绩低下有关。
