• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

探索[具体物质未给出]在多囊卵巢综合征中的治疗潜力：一项计算分析。

Exploring the therapeutic potential of in polycystic ovarian syndrome: a computational analysis.

作者信息

Riaz Sania, Haider Fatima, Ur-Rehman Rizwan-, Zafar Aqsa

机构信息

Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan.

出版信息

J Integr Bioinform. 2024 Dec 12;21(4). doi: 10.1515/jib-2024-0019. eCollection 2024 Dec 1.

DOI:10.1515/jib-2024-0019
PMID:39660761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11698622/
Abstract

PCOS is a multifaceted condition characterized by ovarian abnormalities, metabolic disorders, anovulation, and hormonal imbalances. In response to the growing demand for treatments with fewer side effects, the exploration of herbal-origin drugs has gained prominence. , a traditional medicinal plant that exhibits anti-inflammatory, antioxidant, and anti-androgenic properties may have a cure for PCOS. The plant has rich biochemical profile prompted its exploration as a potential source for drug development. The aim of this study is to investigate the potential therapeutic efficacy of in the management of PCOS through molecular docking studies with Luteinizing Hormone Receptor and Follicle-Stimulating Hormone Receptor proteins. The identified compounds underwent molecular docking against key proteins associated with PCOS, namely Luteinizing Hormone Receptor and Follicle-Stimulating Hormone Receptor. The results underscored the lead compound's superiority, demonstrating favorable pharmacokinetics, ADME characteristics, and strong molecular binding without any observed toxicity in comparison to standard drug. This study, by leveraging natural compounds sourced from , provides valuable insights and advances towards developing more effective and safer treatments for PCOS. The findings contribute to the evolving landscape of PCOS therapeutics, emphasizing the potential of herbal-origin drugs in mitigating the complexities of this syndrome.

摘要

多囊卵巢综合征（PCOS）是一种多方面的病症，其特征为卵巢异常、代谢紊乱、无排卵和激素失衡。随着对副作用较少的治疗方法需求不断增加，对草药来源药物的探索变得愈发重要。一种具有抗炎、抗氧化和抗雄激素特性的传统药用植物可能为多囊卵巢综合征提供治疗方法。该植物丰富的生化特性促使其成为药物开发的潜在来源。本研究的目的是通过与促黄体生成素受体和促卵泡激素受体蛋白进行分子对接研究，探讨该植物在多囊卵巢综合征治疗中的潜在疗效。所鉴定的化合物针对与多囊卵巢综合征相关的关键蛋白，即促黄体生成素受体和促卵泡激素受体进行了分子对接。结果突出了先导化合物的优势，与标准药物相比，显示出良好的药代动力学、药物代谢动力学特性以及强烈的分子结合力，且未观察到任何毒性。本研究通过利用从该植物中提取的天然化合物，为开发更有效、更安全的多囊卵巢综合征治疗方法提供了有价值的见解和进展。这些发现有助于多囊卵巢综合征治疗领域的不断发展，强调了草药来源药物在缓解该综合征复杂性方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/47bb0aa8faf1/j_jib-2024-0019_fig_011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/453738b9ad0e/j_jib-2024-0019_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/c76081cda69a/j_jib-2024-0019_fig_101.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/5ad8e8217aca/j_jib-2024-0019_fig_102.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/0eb4ee2d5080/j_jib-2024-0019_fig_103.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/8dc4ba0fb2e6/j_jib-2024-0019_fig_104.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/70c873383d04/j_jib-2024-0019_fig_105.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/81c5cdd808aa/j_jib-2024-0019_fig_106.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/dee7bb0f9fde/j_jib-2024-0019_fig_107.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/646096b33245/j_jib-2024-0019_fig_108.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/a5cb8160004c/j_jib-2024-0019_fig_109.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/5219ee6b8c2d/j_jib-2024-0019_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/ca24ed6f714e/j_jib-2024-0019_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/a53c790cf89b/j_jib-2024-0019_fig_110.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/bd7dfff7e321/j_jib-2024-0019_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/536bdb9c8496/j_jib-2024-0019_fig_005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/77d84aabeae3/j_jib-2024-0019_fig_006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/eef31b774dbb/j_jib-2024-0019_fig_007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/7414db35167b/j_jib-2024-0019_fig_008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/aee4ca37b294/j_jib-2024-0019_fig_009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/1958aa7b44a7/j_jib-2024-0019_fig_010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/47bb0aa8faf1/j_jib-2024-0019_fig_011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/453738b9ad0e/j_jib-2024-0019_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/c76081cda69a/j_jib-2024-0019_fig_101.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/5ad8e8217aca/j_jib-2024-0019_fig_102.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/0eb4ee2d5080/j_jib-2024-0019_fig_103.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/8dc4ba0fb2e6/j_jib-2024-0019_fig_104.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/70c873383d04/j_jib-2024-0019_fig_105.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/81c5cdd808aa/j_jib-2024-0019_fig_106.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/dee7bb0f9fde/j_jib-2024-0019_fig_107.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/646096b33245/j_jib-2024-0019_fig_108.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/a5cb8160004c/j_jib-2024-0019_fig_109.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/5219ee6b8c2d/j_jib-2024-0019_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/ca24ed6f714e/j_jib-2024-0019_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/a53c790cf89b/j_jib-2024-0019_fig_110.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/bd7dfff7e321/j_jib-2024-0019_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/536bdb9c8496/j_jib-2024-0019_fig_005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/77d84aabeae3/j_jib-2024-0019_fig_006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/eef31b774dbb/j_jib-2024-0019_fig_007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/7414db35167b/j_jib-2024-0019_fig_008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/aee4ca37b294/j_jib-2024-0019_fig_009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/1958aa7b44a7/j_jib-2024-0019_fig_010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99c/11698622/47bb0aa8faf1/j_jib-2024-0019_fig_011.jpg

相似文献

1
Exploring the therapeutic potential of in polycystic ovarian syndrome: a computational analysis.探索[具体物质未给出]在多囊卵巢综合征中的治疗潜力：一项计算分析。
J Integr Bioinform. 2024 Dec 12;21(4). doi: 10.1515/jib-2024-0019. eCollection 2024 Dec 1.
2
Exploring the therapeutic potential of marjoram (Origanum majorana L.) in polycystic ovary syndrome: insights from serum metabolomics, network pharmacology and experimental validation.探索墨角兰（牛至）在多囊卵巢综合征中的治疗潜力：来自血清代谢组学、网络药理学及实验验证的见解
BMC Complement Med Ther. 2025 Feb 21;25(1):67. doi: 10.1186/s12906-025-04774-5.
3
Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats.三角榕改善来曲唑诱导多囊卵巢综合征大鼠的生化、激素和组织形态计量学变化。
BMC Complement Med Ther. 2021 Nov 29;21(1):291. doi: 10.1186/s12906-021-03452-6.
4
Effect of Parquetina nigrescens (Afzel.) Leaves on Letrozole-Induced PCOS in Rats: a Molecular Insight into Its Phytoconstituents.山黧豆叶对来曲唑诱导多囊卵巢综合征大鼠的作用：其植物成分的分子研究。
Appl Biochem Biotechnol. 2023 Aug;195(8):4744-4774. doi: 10.1007/s12010-023-04537-3. Epub 2023 May 12.
5
Effect of Rhei Radix Et Rhizome on treatment of polycystic ovary syndrome by regulating PI3K/AKT pathway and targeting EGFR/ALB in rats.大黄根茎对大鼠多囊卵巢综合征的治疗作用：通过调节PI3K/AKT通路及靶向EGFR/ALB
J Ethnopharmacol. 2025 Feb 10;338(Pt 1):119020. doi: 10.1016/j.jep.2024.119020. Epub 2024 Nov 2.
6
Mitigation of letrozole induced polycystic ovarian syndrome associated inflammatory response and endocrinal dysfunction by Vitex negundo seeds.蔓荆子减轻来曲唑诱导的多囊卵巢综合征相关炎症反应及内分泌功能紊乱。
J Ovarian Res. 2024 Apr 8;17(1):76. doi: 10.1186/s13048-024-01378-4.
7
Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome.促性腺激素释放肽治疗可诱导临床前模型和多囊卵巢综合征女性的促性腺激素反应，并恢复排卵。
Hum Reprod. 2019 Dec 1;34(12):2495-2512. doi: 10.1093/humrep/dez205.
8
Liuwei Dihuang Pills alleviate the polycystic ovary syndrome with improved insulin sensitivity through PI3K/Akt signaling pathway.六味地黄丸通过 PI3K/Akt 信号通路改善胰岛素敏感性，从而缓解多囊卵巢综合征。
J Ethnopharmacol. 2020 Mar 25;250:111965. doi: 10.1016/j.jep.2019.111965. Epub 2019 Jun 8.
9
Regulation of the EGFR/PI3K/AKT signaling cascade using the Shengui Yangrong Decoction improves ovulation dysfunction and insulin resistance in polycystic ovary syndrome.使用参桂养荣汤调节表皮生长因子受体/磷脂酰肌醇-3激酶/蛋白激酶B信号级联反应可改善多囊卵巢综合征的排卵功能障碍和胰岛素抵抗。
Fitoterapia. 2025 Apr;182:106407. doi: 10.1016/j.fitote.2025.106407. Epub 2025 Feb 18.
10
Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst) in Polycystic Ovary Syndrome (PCOS).一种新型胡芦巴籽提取物（葫芦巴，Furocyst）治疗多囊卵巢综合征（PCOS）的疗效。
Int J Med Sci. 2015 Oct 3;12(10):825-31. doi: 10.7150/ijms.13024. eCollection 2015.

本文引用的文献

1
Hormonal changes in PCOS.多囊卵巢综合征的激素变化。
J Endocrinol. 2024 Feb 15;261(1). doi: 10.1530/JOE-23-0342. Print 2024 Apr 1.
2
Burden of polycystic ovary syndrome in the Middle East and North Africa region, 1990-2019.多囊卵巢综合征在中东和北非地区的负担，1990-2019 年。
Sci Rep. 2022 Apr 29;12(1):7039. doi: 10.1038/s41598-022-11006-0.
3
Autoimmunity to the Follicle-Stimulating Hormone Receptor (FSHR) and Luteinizing Hormone Receptor (LHR) in Polycystic Ovarian Syndrome.多囊卵巢综合征中卵泡刺激素受体 (FSHR) 和黄体生成素受体 (LHR) 的自身免疫。
Int J Mol Sci. 2021 Dec 20;22(24):13667. doi: 10.3390/ijms222413667.
4
Actions and Roles of FSH in Germinative Cells.FSH 在生殖细胞中的作用和角色。
Int J Mol Sci. 2021 Sep 18;22(18):10110. doi: 10.3390/ijms221810110.
5
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.卵巢自噬与多囊卵巢综合征：作用、争议与未来展望。
Autophagy. 2021 Oct;17(10):2706-2733. doi: 10.1080/15548627.2021.1938914. Epub 2021 Jun 23.
6
Evaluating the oestrogenic activities of aqueous root extract of Lam in female Sprague-Dawley rats and its phytochemical screening using Gas Chromatography-Mass Spectrometry (GC/MS).评估拉姆水生根提取物对雌性斯普拉格-道利大鼠的雌激素活性，并使用气相色谱-质谱联用仪（GC/MS）对其进行植物化学筛选。
PeerJ. 2019 Jul 19;7:e7254. doi: 10.7717/peerj.7254. eCollection 2019.
7
Impact of stress on female reproductive health disorders: Possible beneficial effects of shatavari (Asparagus racemosus).压力对女性生殖健康障碍的影响：雪蛤（芦笋）可能具有有益作用。
Biomed Pharmacother. 2018 Jul;103:46-49. doi: 10.1016/j.biopha.2018.04.003. Epub 2018 Apr 7.
8
Ovarian Follicular Theca Cell Recruitment, Differentiation, and Impact on Fertility: 2017 Update.卵巢卵泡膜细胞募集、分化及其对生育的影响：2017 年更新。
Endocr Rev. 2018 Feb 1;39(1):1-20. doi: 10.1210/er.2017-00164.
9
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.SwissADME：一个免费的网络工具，用于评估小分子的药代动力学、类药性和药物化学友善性。
Sci Rep. 2017 Mar 3;7:42717. doi: 10.1038/srep42717.
10
The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis.多囊卵巢综合征的患病率及表型特征：一项系统评价与荟萃分析
Hum Reprod. 2016 Dec;31(12):2841-2855. doi: 10.1093/humrep/dew218. Epub 2016 Sep 22.