Haniffadli Ariranur, Ban Yeongjun, Rahmat Endang, Kang Chang Ho, Kang Youngmin
Korean Medicine Convergence Science Major of KIOM School, University of Science and Technology (UST), Daejeon, 34113, Republic of Korea.
Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine (KIOM), 111 Geonjae-Ro, Naju-Si, Jeollanam-Do, 58245, Republic of Korea.
Appl Microbiol Biotechnol. 2024 Dec 11;108(1):534. doi: 10.1007/s00253-024-13369-y.
Metschnikowia, the single-cell yeast form, is a genus of 85 species in the Saccharomycetales order that developed in both aquatic and terrestrial ecosystems after being found in 1899. This yeast is commonly used to control microbial populations in many biological and artificial conditions, such as fermentation. However, current study of Metschnikowia is limited to biological control features rather than researching on lucrative sectors such as beverage production, bioconversion manufacturing, cosmetics, and the pharmaceutical industry. This review summarizes numerous possible applications of Metschnikowia in human life, including potential secondary metabolites in industrial fields such as cosmetics and pharmaceuticals. Furthermore, Metschnikowia-yeast interaction is mentioned as a potential area for further exploration in terms of co-cultured microbes as biocontrol. Since Metschnikowia yeast arose in a variety of ecosystems, more discussion will be held regarding the interactions between Metschnikowia and their surroundings, particularly in fruits. Finally, the current regulatory challenges of Metschnikowia-based products are examined, and future research opportunities on Metschnikowia utilization are presented. KEY POINTS: • Utilization of Metschnikowia genus in various human aspects. • Promising secondary metabolites produced by Metschnikowia. • Challenge and opportunity on developing Metschnikowia-based products.
梅奇尼科夫酵母属为单细胞酵母形态，是酵母目下一个拥有85个物种的属，于1899年被发现后在水生和陆地生态系统中均有发展。这种酵母常用于在许多生物和人工条件下控制微生物种群，比如发酵过程。然而，目前对梅奇尼科夫酵母属的研究仅限于其生物防治特性，而非对诸如饮料生产、生物转化制造、化妆品及制药行业等利润丰厚领域的研究。本综述总结了梅奇尼科夫酵母属在人类生活中的众多可能应用，包括在化妆品和制药等工业领域潜在的次生代谢产物。此外，梅奇尼科夫酵母与其他酵母的相互作用被提及，作为共培养微生物作为生物防治手段的一个有待进一步探索的潜在领域。由于梅奇尼科夫酵母出现在多种生态系统中，因此将更多地讨论梅奇尼科夫酵母与其周围环境的相互作用，特别是在水果中的相互作用。最后，研究了基于梅奇尼科夫酵母属产品当前面临的监管挑战，并提出了未来利用梅奇尼科夫酵母属的研究机会。要点：• 梅奇尼科夫酵母属在人类各个方面的利用。• 梅奇尼科夫酵母属产生的有前景的次生代谢产物。• 开发基于梅奇尼科夫酵母属产品面临的挑战与机遇。
