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高表达的STAT1在内皮细胞中激活TREM1介导的MAPK信号通路，这与颅内动脉瘤的发生和破裂有关。

Activated TREM1-mediated MAPK signaling in endothelial cells caused by highly expressed STAT1 is associated with intracranial aneurysms occurrence and rupture.

作者信息

Zhu Hao, Gao Ge, Wu Yingang, Wang Yang, Chen Yu, Niu Chaoshi

机构信息

Cheeloo College of Medicine, Shandong University, No.44 Wenhua West Road, Lixia District, Jinan, 250012, China.

Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No.1 Swan Lake Road, Hefei, 230001, China.

出版信息

Mol Cell Biochem. 2025 May;480(5):3133-3145. doi: 10.1007/s11010-024-05173-z. Epub 2024 Dec 11.

DOI:10.1007/s11010-024-05173-z
PMID:39661286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12048450/
Abstract

Intracranial aneurysm (IA) poses significant health risks, yet the specific mRNA profiles and regulatory mechanisms distinguishing unruptured IA (UIA) from ruptured IA (RIA) remain unclear. This study aimed to elucidate these differences through comprehensive mRNA analysis. We employed RNA sequencing to compare mRNA expression patterns among control individuals, UIA patients, and RIA patients. Differential expression analysis identified triggering receptor expressed on myeloid cells 1 (TREM1) as a potential biomarker for IA occurrence and rupture, which was validated in an expanded cohort. In vitro experiments revealed that TREM1 overexpression in human umbilical vein endothelial cells (HUVECs) inhibited proliferation, angiogenesis, and migration while promoting apoptosis and inflammation. Bioinformatic predictions and subsequent chromatin immunoprecipitation assays confirmed signal transducer and activator of transcription 1 (STAT1) as a transcriptional regulator of TREM1. STAT1 overexpression in HUVECs activated the MAPK signaling pathway and mimicked the effects of TREM1 overexpression, which were reversible by TREM1 inhibition. Conversely, P38 MAPK inhibition produced opposite effects, which were negated by STAT1 overexpression. This study identifies TREM1 as a potential biomarker for IA occurrence and rupture, likely regulated by STAT1, offering new avenues for non-invasive IA intervention strategies.

摘要

颅内动脉瘤（IA）会带来重大健康风险，但区分未破裂颅内动脉瘤（UIA）和破裂颅内动脉瘤（RIA）的特定mRNA谱及调控机制仍不清楚。本研究旨在通过全面的mRNA分析阐明这些差异。我们采用RNA测序来比较对照个体、UIA患者和RIA患者之间的mRNA表达模式。差异表达分析确定髓系细胞触发受体1（TREM1）是IA发生和破裂的潜在生物标志物，并在一个扩大的队列中得到验证。体外实验表明，人脐静脉内皮细胞（HUVECs）中TREM1过表达会抑制增殖、血管生成和迁移，同时促进细胞凋亡和炎症。生物信息学预测及随后的染色质免疫沉淀实验证实信号转导和转录激活因子1（STAT1）是TREM1的转录调节因子。HUVECs中STAT1过表达激活了MAPK信号通路，并模拟了TREM1过表达的作用，而TREM1抑制可使其作用逆转。相反，P38 MAPK抑制产生相反的效果，而STAT1过表达可消除这种效果。本研究确定TREM1是IA发生和破裂的潜在生物标志物，可能受STAT1调控，为非侵入性IA干预策略提供了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/a7c8ba9e2603/11010_2024_5173_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/929cd04cbd4b/11010_2024_5173_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/d176c2950071/11010_2024_5173_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/af123e331e9c/11010_2024_5173_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/152698eab084/11010_2024_5173_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/883b2fdfcbf1/11010_2024_5173_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/a7c8ba9e2603/11010_2024_5173_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/929cd04cbd4b/11010_2024_5173_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/d176c2950071/11010_2024_5173_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/af123e331e9c/11010_2024_5173_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/152698eab084/11010_2024_5173_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/883b2fdfcbf1/11010_2024_5173_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/051a/12048450/a7c8ba9e2603/11010_2024_5173_Fig6_HTML.jpg

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Eur J Histochem. 2024 Sep 17;68(3):4034. doi: 10.4081/ejh.2024.4034.
2
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Brain Res. 2024 Apr 1;1828:148759. doi: 10.1016/j.brainres.2024.148759. Epub 2024 Jan 17.
3
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4
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Front Immunol. 2023 Jul 3;14:1169560. doi: 10.3389/fimmu.2023.1169560. eCollection 2023.
5
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