自由呼吸非门控径向同步多层心脏T1映射
Free-Breathing Ungated Radial Simultaneous Multi-Slice Cardiac T1 Mapping.
作者信息
Le Johnathan V, Mendes Jason K, Sideris Konstantinos, Bieging Erik, Carter Spencer, Stehlik Josef, DiBella Edward V R, Adluru Ganesh
机构信息
Utah Center for Advanced Imaging Research (UCAIR), Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.
Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA.
出版信息
J Magn Reson Imaging. 2025 Jun;61(6):2587-2600. doi: 10.1002/jmri.29676. Epub 2024 Dec 11.
BACKGROUND
Modified Look-Locker imaging (MOLLI) T1 mapping sequences are acquired during breath-holding and require ECG gating with consistent R-R intervals, which is problematic for patients with atrial fibrillation (AF). Consequently, there is a need for a free-breathing and ungated framework for cardiac T1 mapping.
PURPOSE
To develop and evaluate a free-breathing ungated radial simultaneous multi-slice (SMS) cardiac T1 mapping (FURST) framework.
STUDY TYPE
Retrospective, nonconsecutive cohort study.
POPULATION
Twenty-four datasets from 17 canine and 7 human subjects (4 males, years; 3 females, years). Canines were from studies involving AF induction and ablation treatment. The human population included separate subjects with suspected microvascular disease, acute coronary syndrome with persistent AF, and transthyretin amyloidosis with persistent AF. The remaining human subjects were healthy volunteers.
FIELD STRENGTH/SEQUENCE: Pre- and post-contrast T1 mapping with the free-breathing and ungated SMS inversion recovery sequence with gradient echo readout and with conventional MOLLI sequences at 1.5 T and 3.0 T.
ASSESSMENT
MOLLI and FURST were acquired in all subjects, and American Heart Association (AHA) segmentation was used for segment-wise analysis. Pre-contrast T1, post-contrast T1, and ECV were analyzed using correlation and Bland-Altman plots in 13 canines and 7 human subjects. T1 difference box plots for repeated acquisitions in four canine subjects were used to assess reproducibility. The PIQUE image quality metric was used to evaluate the perceptual quality of T1 maps.
STATISTICAL TESTS
Paired t-tests were used for all comparisons between FURST and MOLLI, with indicating statistical significance.
RESULTS
There were no significant differences between FURST and MOLLI pre-contrast T1 reproducibility ( and , ), FURST and MOLLI ECV ( and , ), or FURST and MOLLI PIQUE scores ( and , ). The ECV mean difference was with .
CONCLUSIONS
FURST had similar quality pre-contrast T1, post-contrast T1, and ECV maps and similar reproducibility compared to MOLLI.
LEVEL OF EVIDENCE
3 TECHNICAL EFFICACY: 1.
背景
改良Look-Locker成像（MOLLI）T1映射序列在屏气期间采集，需要心电门控且R-R间期一致，这对心房颤动（AF）患者来说存在问题。因此，需要一种用于心脏T1映射的自由呼吸且非门控的框架。
目的
开发并评估一种自由呼吸非门控的径向同时多层（SMS）心脏T1映射（FURST）框架。
研究类型
回顾性、非连续队列研究。
研究对象
来自17只犬和7名人类受试者（4名男性，年龄[未提及]；3名女性，年龄[未提及]）的24个数据集。犬来自涉及房颤诱导和消融治疗的研究。人类受试者包括疑似微血管疾病、伴有持续性房颤的急性冠状动脉综合征以及伴有持续性房颤的转甲状腺素蛋白淀粉样变性的单独受试者。其余人类受试者为健康志愿者。
场强/序列：在1.5 T和3.0 T下，使用自由呼吸非门控的具有梯度回波读出的SMS反转恢复序列以及传统的MOLLI序列进行对比剂前和对比剂后T1映射。
评估
对所有受试者采集MOLLI和FURST，并使用美国心脏协会（AHA）分割进行逐段分析。在13只犬和7名人类受试者中，使用相关性和Bland-Altman图分析对比剂前T1、对比剂后T1和细胞外容积（ECV）。使用4只犬受试者重复采集的T1差异箱线图评估可重复性。使用PIQUE图像质量指标评估T1图的感知质量。
统计检验
使用配对t检验对FURST和MOLLI之间的所有比较进行分析，P<0.05表示具有统计学意义。
结果
FURST和MOLLI在对比剂前T1可重复性（P=0.83和P=0.77，P>0.05）、FURST和MOLLI的ECV（P=0.86和P=0.74，P>0.05）或FURST和MOLLI的PIQUE评分（P=0.81和P=0.78，P>0.05）方面均无显著差异。ECV平均差异为0.002±0.023，P=0.94。
结论
与MOLLI相比，FURST在对比剂前T1、对比剂后T1和ECV图方面具有相似的质量和相似的可重复性。
证据水平
3级 技术效能：1级
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