Xiao Songlin, Zhang Chuyi, Shen Bin, Xu Zhen, Li Jingjing, Zhan Jianglong, Zhou Junhong, Fu Weijie
Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, CHINA.
Med Sci Sports Exerc. 2025 May 1;57(5):885-894. doi: 10.1249/MSS.0000000000003626. Epub 2024 Dec 10.
This study aimed to investigate differences in cortical activation between individuals with and without chronic ankle instability (CAI) during a dorsi-plantarflexion task and further explore its association with sensorimotor function.
In this cross-sectional study, 62 participants were recruited, including 31 adults with CAI and 31 healthy adults. Sensorimotor functions, including joint position sense and force sense, were tested using absolute error associated with joint position reproduction and force reproduction tasks. A block design was used to collect task-state functional magnetic resonance imaging by using a custom-built, Magnetic resonance imaging-compatible device during a dorsi-plantarflexion task.
Individuals with CAI showed significantly worse joint position sense and force sense in all four movement directions than those without CAI. Chronic ankle instability is significantly associated with lower cortical activation in the sensorimotor network, mainly including the right postcentral gyrus, right supplementary motor area (SMA) and left precentral gyrus. A weaker functional connectivity was found between the right putamen cluster and the left precentral gyrus in CAI. Greater associations between plantarflexion position sense with cortical activation were observed in the left precentral gyrus, bilateral putamen, and right SMA in CAI, but not in healthy controls.
Individuals with CAI had worse sensorimotor function, experienced lower task-related cortical activation in the sensorimotor network, and had a weaker resting-state functional connectivity between the putamen with the left precentral gyrus compared with healthy controls. Plantarflexion position sense was negatively associated with cortical activation in the left precentral gyrus, bilateral putamen and right SMA in individuals with CAI, but not in healthy controls. These findings suggested that impaired sensorimotor function partly corresponded to potential neurophysiological alterations in individuals with CAI.
本研究旨在调查慢性踝关节不稳（CAI）患者与非慢性踝关节不稳患者在背屈-跖屈任务期间皮质激活的差异，并进一步探讨其与感觉运动功能的关联。
在这项横断面研究中，招募了62名参与者，包括31名患有CAI的成年人和31名健康成年人。使用与关节位置再现和力量再现任务相关的绝对误差来测试包括关节位置觉和力量觉在内的感觉运动功能。在背屈-跖屈任务期间，使用定制的、与磁共振成像兼容的设备，采用组块设计来收集任务状态功能磁共振成像数据。
与非CAI患者相比，CAI患者在所有四个运动方向上的关节位置觉和力量觉均明显更差。慢性踝关节不稳与感觉运动网络中较低的皮质激活显著相关，主要包括右侧中央后回、右侧辅助运动区（SMA）和左侧中央前回。在CAI患者中，右侧壳核簇与左侧中央前回之间的功能连接较弱。在CAI患者中，观察到跖屈位置觉与左侧中央前回、双侧壳核和右侧SMA的皮质激活之间有更强的关联，但在健康对照组中未观察到。
与健康对照组相比，CAI患者的感觉运动功能较差，在感觉运动网络中经历了较低的任务相关皮质激活，并且壳核与左侧中央前回之间的静息态功能连接较弱。在CAI患者中，跖屈位置觉与左侧中央前回、双侧壳核和右侧SMA的皮质激活呈负相关，但在健康对照组中并非如此。这些发现表明，感觉运动功能受损部分对应于CAI患者潜在的神经生理学改变。
